411 results
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Cold Agglutinin ... or fingers • Acrocyanosis ... • Symptoms of anemia ... • hemolytic anemia ... disease #hemolytic #anemia
Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table

Warm AIHA (48-70%)
Cold AHA (16-32%)
 • Donath-Landsteiner HA (paroxysmal
Autoimmune Hemolytic Anemia ... hemoglobinuria) • Cold Agglutinin ... Autoimmune #Hemolytic #Anemia
Summary Table of Causes of Acrocyanosis:

Dr. Ann Marie Kumfer @AnnKumfer

#Acrocyanosis #Differential #Causes #Diagnosis #Causes #Table
Table of Causes of Acrocyanosis ... @AnnKumfer #Acrocyanosis
Differential Diagnosis of Anemias #Diagnosis #IM #Honc #Anemia #Differential #Iron #Algorithm #Microcytic #Macrocytic #Normocytic #Ddxof
Differential Diagnosis of Anemias ... Diagnosis #IM #Honc #Anemia
Hemolytic Anemias - Differential Diagnosis Algorithm

Signs of anemia and hemolysis:
 • ↓ Haptoglobin
 • ↑ LDH
Hemolytic Anemias ... Algorithm Signs of anemia ... Autoimmune Hemolytic Anemias ... Alloimmune Hemolytic Anemias ... #Hemolytic #Anemias
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Agglutination - Cold agglutinins ... ARUPLabs #Hemolytic #Anemia
Common Raynaud's Mimickers
 - Acrocyanosis
 - Chill blains (pernio)
 - Erythromelalgia
 - Frostbite
 - Achenbach's Syndrome

Dr.
Mimickers - Acrocyanosis
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Microangiopathic hemolytic anemia ... . primary cold agglutin ... diagnosis #hematology #anemia
perioral cyanosis- A blue color around the lips and philtrum is a relatively common finding shortly
This is part of acrocyanosis ... perioral #cyanosis #acrocyanosis
Expected DAT Results in Autoimmune Hemolysis
DAT Negative Hemolysis
 • DAT Poly ( - ), IgG (
( +/- ) Cold agglutinin