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differential hemolytic causes hemolysis agglutinin autoimmune classification extravascular intravascular monoclonal oncology paraproteinemias table
Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table Warm AIHA (48-70%) Cold AHA (16-32%) • Donath-Landsteiner HA (paroxysmal
Diagnosis Table ... Warm AIHA (48 ... -70%) Cold AHA ... Agglutinin Disease ... #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... - Autoimmune (AIHA ... )"Cold" (usually ... (e.g. primary cold ... #hematology #anemia
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
women • 15% of AIHA ... or fingers • Acrocyanosis ... anemia • Cold ... Mycoplasma, EBV, HIV ... #hematology #diagnosis
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
- Differential Diagnosis ... - Autoimmune: Warm ... AIHA, Cold AIHA ... Defects: Sickle cell anemia ... #hematology
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Differential Diagnosis ... Causes: • Liver disease ... Hypersplenism • AIHA ... : warm, cold, drug ... classification #hematology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Coagulopathy) SMZL: • AIHA ... (-) hemolytic anemia ... due to cold IgG ... Paraproteinemias #Hematology ... #Differential #Diagnosis
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