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Acromegaly - Diagnosis and Management Summary - GrepMed Handbook 

Clinical Presentation: 
 • Classic Acromegaly: frontal
Acromegaly - Diagnosis ... and Management ... : • Classic Acromegaly ... macrognathia), ↑ hand ... resistance pseudo-acromegaly
Growth Hormone Excess - Pathogenesis and clinical findings
 • Acromegaly and gigantism share the same pathophysiology
clinical findings • Acromegaly ... GH excess prior ... GH excess after ... plate fusion -> acromegaly ... rare causes of acromegaly
Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
Growth Hormone (GH ... activates osteoblasts and ... /Symptoms: • GH ... - Giantism or acromegaly ... , widening of hands
Acromegaly 
Caused by over-secretion of growth hormone (GH) from the pituitary gland. 
The condition is rare
Acromegaly Caused ... growth hormone (GH ... condition is rare and ... present between 30 and ... #Acromegaly #Signs
Tall Stature - Differential Diagnosis Algorithm

Normal Growth (BA=CA)
 • Familial Tall Stature
 • XYY Syndrome
Obese BMI
Puberty Onset • GH ... Resistance • Acromegaly
Acromegalic Hand: Markedly enlarged hand resulting from excess growth hormone. For reference
purposes, the comparison hand is
Acromegalic Hand ... Markedly enlarged hand ... the comparison hand ... Clinical #Photo #Acromegaly ... #Acromegalic #Hand
#ACROMEGALY #management #algorithm #treatment
#ACROMEGALY #management
Hirsutism - Differential Diagnosis
Defined as excessive dark, coarse, male-pattern hair growth
Hirsutism causes in premenopausal women:
 •
Cushing's Syndrome, Acromegaly ... Cushing's Syndrome, Acromegaly ... Pucci @gabifpucci and
Multiple Endocrine Neoplasias (MEN syndromes) 

MEN I
• Hyperparathyroidism 
• Hypercalcemia 
• Possible ZE syndrome 
• Various
Pituitary path • Acromegaly
Sellar / Pituitary Mass - Differential Diagnosis Algorithm
Adenoma - Primary Anterior Pituitary
 - Secreting
Prolactin • GH