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Acromegaly - Diagnosis and Management Summary - GrepMed Handbook 

Clinical Presentation: 
 • Classic Acromegaly: frontal
Acromegaly - Diagnosis ... : • Classic Acromegaly ... resistance pseudo-acromegaly ... Beckwith Wiedemann syndrome ... thakre_anuj) #Acromegaly
Growth Hormone Excess - Pathogenesis and clinical findings
 • Acromegaly and gigantism share the same pathophysiology
clinical findings • Acromegaly ... GH excess prior ... plate fusion -> acromegaly ... rare causes of acromegaly ... Carpal Tunnel Syndrome
Acromegaly 
Caused by over-secretion of growth hormone (GH) from the pituitary gland. 
The condition is rare
Acromegaly Caused ... growth hormone (GH ... #Acromegaly #Signs
Acromegalic Hand: Markedly enlarged hand resulting from excess growth hormone. For reference
purposes, the comparison hand is
Acromegalic Hand ... Goldberg, M.D. - UCSD ... Clinical #Photo #Acromegaly ... #Acromegalic #Hand ... #UCSDH
Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
Growth Hormone (GH ... /Symptoms: • GH ... abn lipid • GH ... - Giantism or acromegaly ... GrowthHormone #GH
Tall Stature - Differential Diagnosis Algorithm

Normal Growth (BA=CA)
 • Familial Tall Stature
 • XYY Syndrome
Obese BMI
Stature • XYY Syndrome ... Puberty Onset • GH ... • Soto's Syndrome ... Resistance • Acromegaly ... • XYY Syndrome
Cutis Verticis Gyrata: Idiopathic development of excess folds and furrows within the skin of the head.
Associated
mental retardation, acromegaly ... Goldberg, M.D. - UCSD ... Gyrata #Photo #UCSDH
Multiple Endocrine Neoplasias (MEN syndromes) 

MEN I
• Hyperparathyroidism 
• Hypercalcemia 
• Possible ZE syndrome 
• Various
Neoplasias (MEN syndromes ... • Possible ZE syndrome ... Pituitary path • Acromegaly ... • Cushing syndrome
Drug Reaction with Eosinophilia and Systemic Signs (DRESS Syndrome): Formerly known as drug hypersensitivity reaction, DRESS
represents
Systemic Signs (DRESS Syndrome ... Goldberg, M.D. - UCSD ... SkinRash #DRESS #Syndrome ... #Legs #Photo #UCSDH
Drug Reaction with Eosinophilia and Systemic Signs (DRESS Syndrome): Formerly known as drug hypersensitivity reaction, DRESS
represents
Systemic Signs (DRESS Syndrome ... Goldberg, M.D. - UCSD ... SkinRash #DRESS #Syndrome ... Eosinophilia #Photo #UCSDH