224 results
Growth Hormone Excess - Pathogenesis and clinical findings
 • Acromegaly and gigantism share the same pathophysiology
clinical findings • Acromegaly ... plate fusion -> acromegaly ... rare causes of acromegaly ... Carpal Tunnel Syndrome ... fraction • HTN #GrowthHormone
Multiple Endocrine Neoplasias (MEN syndromes) 

MEN I
• Hyperparathyroidism 
• Hypercalcemia 
• Possible ZE syndrome 
• Various
Neoplasias (MEN syndromes ... • Possible ZE syndrome ... Pituitary path • Acromegaly ... • Cushing syndrome
#ACROMEGALY #management #algorithm #treatment
#ACROMEGALY #management
Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
- Giantism or acromegaly ... metabolic abn #GrowthHormone
Hirsutism - Differential Diagnosis
Defined as excessive dark, coarse, male-pattern hair growth
Hirsutism causes in premenopausal women:
 •
Rare: Cushing's Syndrome ... , Acromegaly, Androgen-secreting ... Ovary • Cushing's Syndrome ... , Acromegaly
Acromegaly - Diagnosis and Management Summary - GrepMed Handbook 

Clinical Presentation: 
 • Classic Acromegaly: frontal
Acromegaly - Diagnosis ... and Management ... Beckwith Wiedemann syndrome ... MRI+contrast Management ... #Diagnosis #Management
Inherited Colorectal Cancer (CRS) Syndromes
Adenomatous Polyposis Syndromes:
 • Familial Adenomatous Polyposis (FAP), Attenuated FAP (AFAP), MUTYH
Colorectal Cancer (CRS) Syndromes ... Adenomatous Polyposis Syndromes ... Urinary → Lynch Syndrome ... Peutz-Jeghers Syndrome ... #diagnosis #management
Secondary causes of Hypertension
 • Medications, Drugs, Chemo: NSAIDS, Steroids, CNI, Alcohol, Cocaine, OCP, Licorice, MAOI,
Hyperparathyroidism, Acromegaly ... tumor, Chrouros syndrome ... , Geller syndrome ... , Gordon syndrome ... , Liddle syndrome
Tall Stature - Differential Diagnosis Algorithm

Normal Growth (BA=CA)
 • Familial Tall Stature
 • XYY Syndrome
Obese BMI
Stature • XYY Syndrome ... Klinefelter's Syndrome ... • Soto's Syndrome ... Resistance • Acromegaly ... • XYY Syndrome
Hyperglycemia - Differential Diagnosis Algorithm
Diabetes Mellitus:
 • Impaired Glucose Tolerance
 • Type I Diabetes
 • Type
• Cushing's Syndrome ... • Acromegaly