3438 results
Cardiac Myocyte Contractile cycle
 - Ca2+ binds to TnC → TnI is inhibited → conformational change
site between actin ... interact with active ... releasing the actin ... further along the actin ... Pathophysiology #Cardiology
Membrane Actions of Antiarrhythmic Drugs

#Membrane #Channels #Actions #Antiarrhythmic #Drugs #Medications #Pharmacology #Cardiology #Table
Membrane Actions ... Membrane #Channels #Actions ... #Pharmacology #Cardiology
Class I Antiarrhythmics and their Key Pharmacologic Properties

Class IA = Quinidine, Procainamide, Disopyramide ("Quarter PounDer")
Class IB
fast-response cardiac action ... This type of action ... ) due to their actions ... repolarization of action ... Pharmacology #Agents #Cardiology
Pharmacology of diuretics

Acetazolamide, Loop diuretics, Thiazide‐like diuretics, MRA, Amiloride

Site of Action, Maximum Dose, Half-Life, Onset, Bioavailability,
Amiloride Site of Action ... Thiazide #CHF #Cardiology
Antiarrhythmics - Vaughan Williams Classification:
CLASS 1 - Sodium Channel Blockers:
 • MOA: Block fast Na+ channels
, Intermediate Action ... Blockade, Fast Action ... Blockade, Slow Action ... inotropy) ACCP Cardiology ... pathophysiology #cardiology
Drugs affecting the cardiac action potential. The sharp rise in voltage ("0") corresponds to the influx
affecting the cardiac action ... #Pharmacology #Cardiology
Antiarrhythmics - Vaughan Williams Classification
Class I (Ia, Ib, Ic) - Na+ Channel Blockade
 • Slows depolarization
Blockade • Prolongs action ... Classification #Classes #cardiology
Antiarrhythmics Pharmacology Summary
Cardiac Conduction Phases:
Phase 0 - Ventricular Depolarization:
 • Na+ channels open leading to a
, Intermediate Action ... Blockade, Fast Action ... Blockade, Slow Action ... inotropy) ACCP Cardiology ... pathophysiology #phases #cardiology
Medications Used in Congestive Heart Failure

In CHF, the heart is failing as a pump; cardiac output
#Medications #Action ... #HeartFailure #Cardiology
Digoxin Pharmacology and Pathophysiology
1) Na/K ATPase Pump - Digoxin works by directly binding to and inhibiting
inhibiting the action ... of the cardiac action ... digoxin blocks the action ... Pathophysiology #cardiology