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Pulmonary Complications Following Stem Cell Transplant

For patients in the pre- engraftment period (day 0-30):
 - 
Pulmonary
Pulmonary Complications ... Following Stem Cell Transplant ... infections - Pulmonary ... with autologous transplant ... influenza, CMV, adenovirus
Transplant Infections Timeline
Pre-transplant:
 • Common bacteria (endogenous): Staphylococci (skin), Gram-negative bacilli (gut)
 • Viruses: HSV (reactivation)
Engraftment:
Transplant Infections ... Timeline Pre-transplant ... reactivation), HHV-6, Adenovirus ... Protozoa: T. gondii #Transplant
Common causes of post-Transplant Diarrhea
 • Bacterial: Clostridium difficile, Campylobacter spp., Salmonella spp., Bacterial overgrowth, Aeromonus
causes of post-Transplant ... Sapovavirus, Rotavirus, Adenovirus ... Malabsorption #Transplant
Hematuria in Post-Renal Transplant Patient
Prevalence up to 12% in the postrenal transplant patient
 • Bacterial: Escherichia
in Post-Renal Transplant ... the postrenal transplant ... polyomavirus, Adenovirus ... Hematuria #Renal #Transplant
Graft-Verus-Host Disease (GVHD) - Quick Reference Sheet
Multisystem disorder that is a common complication of allogeneic hematopoietic
hematopoietic cell transplant ... when immune cells transplanted ... recognize the transplant ... disease in the transplant ... GVHD #CheatSheet #Transplant
Post-Transplantation Lymphoproliferative Disorders (PTLD)
Definition: Lymphoid and/or plasmacytic proliferations that occur as a result of immunosuppression in
of solid-organ transplants ... Risk Factors by transplant ... • Solid organ transplant ... Type of organ transplanted ... diagnosis #management #transplant
Infections in Immunocompromised Patients - Differential Diagnosis Summary
Innate Immunity:
 • Neutropenia
 • Phagocytic Deficiencies
 • Complement
• Solid Organ Transplant ... Allogeneic Stem Cell Transplant ... Deeksha Jandhyala @transplantID
COVID-19 Vaccines - Comparison Chart
 • Moderna - mRNA-1273 mRNA in lipid nanoparticle
 • Pfizer -
Non-replicating Chimp Adenovirus-DNA ... Non-replicating human adenovirus ... - Ad26 and Ad5 adenovirus
Algorithm for Treatment of Chronic Thromboembolic Disease (CTEPH)
Initial Imaging for Screening - V/Q scan - 90-100%
• Assess for Pulmonary ... Operability → Pulmonary ... Therapy • Balloon Pulmonary ... Consider Lung Transplant ... algorithm #cardiology #pulmonary
Keratoconjunctivitis: Inflammation of the conjunctiva and cornea secondary to Adenovirus infection.
Photo credit, Josh Fierer, M.D.

Charlie Goldberg,
cornea secondary to Adenovirus ... Keratoconjunctivitis #Adenovirus