346 results
Primary Adrenal Insufficiency
Addison's Disease - Damage of the adrenal glands with lack of cortisol, androgens and
Primary Adrenal ... aldosterone Causes ... : Most Common Causes ... Tuberculosis: can cause ... insufficiency #addisons
Causes of Metabolic Alkalosis - Differential Diagnosis Algorithm
GI Losses - Gastric
 • Vomiting
 • NG suction
GI
Causes of Metabolic ... Chloridorrhea Renal ... Non-reabsorbed anions ... Aldosterone-secreting mass • Adrenal ... Diagnosis #Algorithm #Causes
CLINICAL MANIFESTATIONS 
OF ADRENAL INSUFFICIENCY. 

Primary and secondary adrenal insufficiency:
 - Tiredness, weakness, mental depression
CLINICAL MANIFESTATIONS ... OF ADRENAL INSUFFICIENCY ... and secondary adrenal ... hypotension - Nausea ... Insufficiency #Addisons
Hypokalemia Differential Diagnosis Algorithm

Low intake 
• poor oral intake 

Renal loss 
• Medication 
• Hypomagnesemia 
•
oral intake Renal ... Nonreabsorbable anions ... • Renal tubular ... Diagnosis #Algorithm #Causes
Hypokalemia - Differential Diagnosis Algorithm
Extra-renal Losses:
 • Normal Acid-Base: Low intake
 • Metabolic acidosis: Gl tract
Algorithm Extra-renal ... loss (Diarrhea) Renal ... Non-reabsorbable anions ... Diagnosis #Algorithm #causes
Hypokalemia Evaluation Algorithm

Before evaluating hypokalemia, life threatening complications such as arrhythmias and paralysis should be looked
wasting from other causes ... suggests extra-renal ... causes • Laxative ... syndrome, Congenital adrenal ... Non-reabsorbable anions
Plain radiography of the abdomen revealed calcification of both adrenal glands. A homozygous mutation in LIPA
calcification of both adrenal ... acid lipase is critical ... and gut, which causes ... #clincial #peds ... NEJM #Wolmans #radiology
Pathological Optic Disc Cupping

Note cup-to-disc ratio at least 0.8 (physiologic limit of 0.5).

Thinning of optic disc
Usual cause is glaucoma ... Glaucoma causes ... of optic nerve axons ... ophthalmology #Clinical
Causes of Adrenal Insufficiency - Differential Diagnosis Algorithm
Autoimmune:
 • Isolated
 • Polyglandular autoimmune syndrome 1
 •
Causes of Adrenal ... Thrombophilia • Critical ... amzn.to/2LmUODZ #Adrenal ... Diagnosis #Algorithm #Causes
Cotton Wool Spots

Caused by microinfarcts. Exploded ganglion cell axons extrude their axoplasm into retina. Long DDx:
Wool Spots Caused ... ganglion cell axons ... ophthalmology #Clinical