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diagnosis laboratory betadglucan disease fungal galactomannan algorithm celiac differential infectiousdiseases sensitivity active activetb adjusted age arthritis aspergillus biomarkers biostatistics calculations
1,3 Beta-D-Glucan and Galactomannan - Pathogens, and Testing Characteristics 1,3 ß-D-glucan: • Most fungi excluding mucor and
Pathogens, and Testing ... and pneumocystis False ... other fungi • False ... Galactomannan #Pathogens #Testing ... #Sensitivity #Specificity
Tuberculosis Testing LATENT TB • LTBI is diagnosed when an asymptomatic patient has a positive TST or IGRA
Tuberculosis Testing ... Tuberculin skin testing ... (TST) False-negative ... recommended because false-negative ... #Diagnosis #Workup
Diagnostic algorithm for the workup of hypercalcemia. The diagnostic workup for patients presenting with hypercalcemia rests
algorithm for the workup ... The diagnostic workup ... ) was 0.80 and specificity ... Thus, further testing ... Hypercalcemia #Workup
1,3-Beta-D-Glucan and Galactomannan Testing Sensitivity Specificity and False Positives 1,3-Beta-D-Glucan • Cell wall component of many fungi
Galactomannan Testing ... Sensitivity Specificity ... and False Positives ... 96% • Higher specificity ... Galactomannan #Fungal #Testing
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan Beta-D-Glucan: • Polysaccharide cell wall component of many fungi • Pathogens:
Sensitivity & Specificity ... 96% - Higher specificity ... breakthrough IFI in HM • False ... recipients, CGD pts • False ... Frozen ice-pops (in setting
Commonly Used Diagnostic Tests for Celiac Disease Tissue transglutaminase (tTG) IgA antibodies - Most reliable noninvasive test
sensitivity and specificity ... sensitivity and specificity ... Celiac #Disease #Testing ... Tests #Diagnosis #Workup
D-dimer Plasma D-dimer is a product of clot breakdown, released upon degradation of polymerized, crosslinked fibrin. Elevated
can cause a ↓ specificity ... (i.e. more false ... Specificity can ... yrs of age) the specificity ... adjusted d-dimer testing
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... - CCP antibody testing ... has higher specificity ... Arthritis #laboratory #workup ... #diagnosis #testing
USMLE Epidemiology and Biostatistics Summary Meta-Analysis: pools data from several studies (greater power), limited by quality/bias of
Specificity (rule ... FN) Higher specificity ... probability of getting ... null when it’s false ... when it is indeed false
Celiac Disease - Diagnosis Algorithm IgA TTG has high sensitivity and specificity of ~ 98% and is
sensitivity and specificity ... pts need further testing ... gastroenterology #workup
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