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management lupus sle erythematosus hematology summary anesthesia anesthesiology checklist comparison crisis differential disease druginduced gap globulin hyperthermia igg4 intraoperative malignant
IgG4-Related Disease Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor 4 phenotypes: •
female, asian • Systemic ... pancreas, biliary, renal ... orientation): ... management #phenotypes #workup ... #treatment #rheumatology
Systemic Sclerosis (Scleroderma) Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs 3
arterial HTN) • Renal ... : scleroderma renal ... Scleroderma #SSc #rheumatology ... #diagnosis #signs ... symptoms #testing #workup
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... (SLE) - Diagnosis ... • Immunologic Workup ... life-threatening • Treatment ... Management #Summary #rheumatology
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Systemic Lupus Erythematosus ... severe disease & renal ... severe disease Treatment ... #SLE #Summary #diagnosis ... #rheumatology #
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
• Immunologic Workup ... months to years) Systemic ... • Immunologic Workup ... comparison #table #rheumatology ... #diagnosis #management
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
TTP - Laboratory Evaluation ... activity is the diagnostic ... available for rapid diagnosis ... the presence of renal ... #Workup #Hematology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Central nervous system ... cirrhosis: 3%-20% Renal ... Distal (Type I) renal ... Adenocarcinoma Treatment ... Sjogrens #Syndrome #Rheumatology
Malignant Hyperthermia Crisis - Guidelines for Crises in Anaesthesia Unexplained increase in ETCO2 AND tachycardia AND increased
❹ Call for MH treatment ... Change breathing system ... ); may require renal ... Intraoperative #Checklist #Diagnosis ... #Management #Workup
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... first step in evaluation ... cancers, HCC, renal ... #differential #diagnosis ... #hematology
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