10 results
Oral anticoagulant dosing and bridging for VTE

- Dr. Joseph Shatzel @Clotmaster 

#VTE #DOAC #Bridging #Dosing #Oral
Anticoagulant #Anticoagulation ... #Dabigatran #Apixaban ... #Rivaroxaban #Edoxaban ... #Loading #DVT #Pharmacology ... #Hematology
Switching Between Anticoagulants and DOACs
VKA, Dabigatran, Rivaroxaban, Apixaban, Edoxaban, Betrixaban, DOAC, Parenteral anticoagulant

DOI: 10.1161/JAHA.120.017559

#Anticoagulants #DOACs #anticoagulation
, Rivaroxaban, Apixaban ... , Edoxaban, Betrixaban ... Anticoagulants #DOACs #anticoagulation ... #Switching #hematology ... #pharmacology
DOAC: Cheat Sheet - Atrial Fibrillation, VTE Prophylaxis, VTE and Renal Dosing

Renal Dosing:
Apixaban (25% renal clearance):
Renal Dosing: Apixaban ... if CrCl < 50) Edoxaban ... AFib: CrCl 15-50 ... OralAnticoagulant #Anticoagulation ... #Hematology #Pharmacology
Anticoagulants Common Reversal Agents
 - Warfarin (Coumadin) → Vitamin K (Phytonadione), 4-factor PCC (Kcentra)
 - Heparin/LMWH
(Praxbind) - Apixaban ... Betrixaban (Bevyxxa), Edoxaban ... PCC (Kcentra) #anticoagulation ... #doac #noac #pharmacology ... #hematology #reversal
Coagulation Cascade - Actions of Anticoagulants
 • Heparin: Unfractionated heparin, Enoxaparin, Daltaparin
 • Fondaparinux
 • Direct
: Rivaroxaban, Apixaban ... , Edoxaban • Vitamin ... - Strong Medicine ... Anticoagulants #anticoagulation ... #pharmacology
Stroke and bleeding risk stratification with the CHADS2-VASc and HAS-BLED schemas

#Diagnosis #Hematology #CHADS2 #CHADS2VASc #HASBLED #Comparison
Stroke and bleeding ... HAS-BLED schemas #Diagnosis ... #Hematology #CHADS2 ... #Bleed #Anticoagulation ... #AFib
Effect of Anticoagulants on Coagulation Tests
PT / INR, aPTT, Anti-Xa Activity, Activated Clotting Time, Thrombin Time,
Rivaroxaban Apixaban ... , Edoxaban Argatroban ... - Strong Medicine ... Anticoagulants #Tests #Anticoagulation ... #Testing #Diagnosis
CHA2DS2VASc vs HAS-BLED scores for stroke risk and bleed risk on anticoagulation

C	Congestive Heart Failure	1

H	Hypertension	1

A2	Age >75	2

D	Diabetes Mellitus	1

S2	Stroke,
HAS-BLED scores for stroke ... bleed risk on anticoagulation ... #Bleed #Anticoagulation ... #AFib #Diagnosis ... #Hematology
Atrial Fibrillation (A-Fib) Summary

Symptoms:
• Palpitations, light-headedness, dizziness, dyspnea, exercise intolerance, chest pain, near-syncope, syncope.

Why?
Cardiac:
	• Valvular heart
control with early Afib ... (< 5% pts with afibb ... (rivaroxaban, apixaban ... , edoxaban) • Warfarin ... #diagnosis #management
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
clot #PT #PTT #diagnosis ... #models #hematology ... pathophysiology #anticoagulation ... thrombin #inhibitor #Apixaban ... #Rivaroxaban #Edoxaban