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diagnosis management algorithm differential hematology checklist treatment evaluation causes clinical pulmonary nephrology anesthesia anesthesiology criticalcare pathophysiology peds thrombocytopenia endocrinology cardiology
Platelet disorders and Aggregometry Glanzmann Thrombasthenia • Defective aggregation to all agonists except ristocetin • Normal platelet,
Platelet disorders ... and Aggregometry ... count and platelet ... • Platelet flow ... differential #diagnosis #Aggregometry
Inherited Qualitative Platelet Defects Bernard-Soulier Syndrome • Defect of adhesion due to a lack of GP Ib/IX/V
Inherited Qualitative Platelet ... Single isolated platelets ... without platelet ... failure Grey Platelet ... • Absence of platelet
Thrombocytosis - Differential Diagnosis Platelet Count > 450 Reactive: • Anemia/blood loss (Fe deficiency) • Infection/Sepsis • Non-infectious
Differential Diagnosis Platelet ... Diagnosis #causes #Platelets
Idiopathic Thrombocytopenic Purpura Clinical: • Gingival • Menorrhagia • GI bleeding • Intracranial
children) • Platelets ... extremely low platelet
Pancytopenia - Differential Diagnosis Algorithm • 12-13 g/dL, • ANC < 1800/uL, • platelet < 150,000/uL Initial
< 1800/uL, • platelet ... /uL Initial Workup ... Algorithm #hematology #workup
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Thrombocytopenia and Platelet ... Diagnosis and Workup ... History: - Prior platelet ... Thrombocytopenia #Platelet ... Diagnosis #Causes #Workup
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Thrombocytosis - Elevated Platelet ... hematology for workup ... Thrombocytosis #Platelets
Blood Product Components, Contents, Volume and Shelf Life Whole blood (autologous or directed donations) - RBC and
WBC and platelets ... Hct 60% Platelet ... concentrate - Platelets ... Hct < .005) Platelet ... pheresis - Platelets
Thromboelastography (TEG) based therapy and Management If r time prolonged -> FFP If MA low -> plts/cryoprecipitate (if
cryoprecipitate If platelets ... < 50 - > platelet
Thromboelastography (TEG) Based Management - If R time prolonged -> FFP - If MA low
cryoprecipitate - If platelets ... < 50 -> platelet
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