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diagnosis rheumatology systemic ana antinuclear classification patterns autoantibodies comparison criteria disease druginduced eularacr laboratory management mimickers rheumatic rheumatoid signs symptoms
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
erythematosus ( ... Juvenile Idiopathic Arthritis ... erythematosus ( ... #Antinuclear #Antibodies ... rheumatology #diagnosis #differential
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Suspect: Clinical ... and permanent alopecia ... Differential ... • Nonscarring alopecia
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
Clinical Domains ... : Non-scarring alopecia ... • Arthritis domain ... Highly specific antibodies ... Classification #Criteria #SLE
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... likely it will be clinically ... erythematosus ( ... erythematosus ( ... rheumatology #diagnosis #differential
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Systemic Lupus Erythematosus ... Manifestations: - Arthritis ... Auto-Antibodies ... Lupusreference #SLE ... #Erythematosus
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
to 1:1 F:M • Clinical ... Constitutional symptoms, Arthritis ... Erythematosus ( ... 40, F:M 9:1 • Clinical ... Photosensitivity, Alopecia
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
inflammation Others: • Lupus ... such as systemic lupus ... erythematosus, ... C-ANCA) pattern: antibodies ... vasculitis, and SLE
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Diseases • Septic arthritis ... joint • Systemic lupus ... erythematosus ( ... double-stranded DNA antibodies ... ANA and RF (if clinical
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