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diagnosis hematology algorithm causes treatment deficiency pancytopenia classification myelodysplastic pathophysiology workup approach ascorbicacid atlas bariatric bloodcell bypass calculation cardiology cardiomyopathy
Aplastic Anemia Summary • Definition • Pathophysiology • DDx: AA vs Hypocellular MDS • Expectation •
Aplastic Anemia ... vs Hypocellular MDS ... @ZhuoerXie #Aplastic ... #Anemia #diagnosis ... #oncology #hematololgy
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
Algorithmic Approach to Anemia ... inflammation) • Iron ... Sideroblastic anemia ... anemia, CKD • ... MatthewHoMD #Anemia
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Causes of Anemia ... • Marrow Aplasia ... Microangiopathic Hemolytic Anemias ... • Early Iron ... #Normocytic #Anemia
Causes of Aplastic Anemia #Aplastic #Anemia #Causes #Pathophysiology #Pathology #Treatment #Management #Differential
Causes of Aplastic ... Anemia #Aplastic ... #Anemia #Causes ... Pathology #Treatment #Management ... #Differential
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
Overall Approach to Anemia ... - Differential ... Deficiency • Aplastic ... Anemia • Anemia ... Non-lmmune #Anemia
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... Anemia Clinical ... anemia) Labs ... #Anemia #oncology
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Aplastic Anemia ... • Symptomatic anemia ... megaloblastic anemia ... Can progress to MDS ... #Anemia #diagnosis
Causes of Neutropenia with Pancytopenia - Differential Diagnosis Algorithm Sequestration: • Splenomegaly Marrow Infiltration: • Hematologic and non-hematologic
Pancytopenia - Differential ... • Toxins • Aplastic ... Anemia • Myelodysplasia ... Nutritional deficiency ... #Neutropenia #Differential
Pancytopenia - Workup and Differential Diagnosis Algorithm Consumption Disorders 1. Autoimmune Mediated Pancytopenia 2. Splenic Sequestration Peripheral Destruction
Pancytopenia - Workup and Differential ... Drugs Nutritional ... FISH • Acquired Aplastic ... Anemia • Hypoplastic ... MDS • Congenital
Causes of Iron Deficiency • Diet: ↓ Intake, e.g. vegan, Malnutrition, Polyphenol / tannins, ↓ Vitamin
Causes of Iron Deficiency ... @drkeithsiau #Iron ... Deficiency #Causes #differential ... #diagnosis #anemia ... #nutrition
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