938 results
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
(Cold-induced symptoms ... of anemia include ... anemia • Cold ... IgM) • Blood smear ... disease #hemolytic #anemia
Chronic Lymphocytic Leukemia (CLL) - Summary
Overview: 
 • Most common leukemia in adults
 • Disorder of
minimal tumor burden Diagnosis ... • Peripheral smear ... of anemia or thrombocytopenia ... marrow failure with anemia ... hematology #hemeonc #diagnosis
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
- Differential Diagnosis ... peripheral blood smear ... pylori test (GI symptoms ... changes), high MCV anemia ... dysplasia on the smear
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
peripheral blood smear ... rapid onset of symptoms ... - infiltrates (anemia ... • Peripheral smear ... Hematology #Oncology #Diagnosis
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
age 70 years Symptoms ... Peripheral Smear ... • Aplastic Anemia ... Peripheral blood smear ... Myelodysplastic #Syndromes #diagnosis
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
with no early symptoms ... phenomenon CLL Diagnosis ... • Peripheral smear ... • Neutropenia, anemia ... Lymphocytic #Leukemia #diagnosis
Hemolytic Anemias - Differential Diagnosis Algorithm

Signs of anemia and hemolysis:
 • ↓ Haptoglobin
 • ↑ LDH
Hemolytic Anemias ... - Differential Diagnosis ... Algorithm Signs of anemia ... Abnormal peripheral smear ... #Differential #Diagnosis
Megaloblastic Anemia vs Normal Peripheral Smear

#Megaloblastic #Anemia #Peripheral #Smear #Comparison #Clinical #Hypersegmented #Neutrophil
Megaloblastic Anemia ... Normal Peripheral Smear ... Megaloblastic #Anemia ... #Peripheral #Smear
Autoimmune Hemolytic Anemia (AIHA) Pathophysiology - Warm vs Cold AIHA
Warm AIHA:
 - 70%; IgG mediated
 -
Autoimmune Hemolytic Anemia ... or negative - Smear ... C3 positive - Smear ... Autoimmune #Hemolytic #Anemia ... Pathophysiology #diagnosis
Laboratory Testing in Hemolytic Anemia

Intravascular vs Extravascular Hemolysis
Reticulocytes
Unconjugated bilirubin
LDH
Peripheral smear
Haptoglobin
Urine hemosiderin
Urine hemoglobin
Carboxyhemoglobin

#Hemolytic #Anemia #Laboratory #Testing #workup
Testing in Hemolytic Anemia ... LDH Peripheral smear ... #Hemolytic #Anemia ... Testing #workup #diagnosis