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diagnosis allergy classification rheumatology comparison differential hypersensitivity management reactions sle bradykinin c3 c4 champs cryoglobulinemia cryoglobulins druginduced erythematosus hematology hypocomplementemia
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
disease, hereditary angioedema ... glomerulonephritis, type ... 1 (50%-80%), type ... S - Systemic Lupus ... Hypocomplementemia #Low #Complement
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
Hypersensitivity Types ... antigen, leading to complement ... Complement activation ... , and systemic lupus ... Diagnosis #Reactions #Table
Summary table of types of hypersensitivity reactions. Type 1 - Mediators: lgE - Antigen Form: Soluble
Summary table of ... antigens, leading to complement ... they activate complement ... glomerulonephritis, Systemic lupus ... #allergy #table
Effect of Selected Diseases on Complement Levels - C3, C4 • SLE C3 ↓ C4 ↓↓
Selected Diseases on Complement ... C4 ↓↓ • MCGN type ... • Hereditary angiooedema ... ThePeanutKidney #Complement
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Drug Induced Lupus ... Drug Induced Lupus ... 90% - Low complement ... 80% - Low complement ... sle #comparison #table
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Types: • Type ... arthritis) • Types ... • Type III Often ... • Low serum C4 complement ... (e.g. systemic lupus
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... anti-Smith Ab, low complements ... Acute cutaneous lupus ... Kikuchi disease • Type-I ... RNP antibodies, Complement
Bradykinin-mediated Angioedema Clinical features: Submucosal oedema (face, extremity, genitalia), Laryngeal dyspnea (25% of deaths), Recurrent attacks of
Bradykinin-mediated Angioedema ... abdominal pain Types ... autoimmune disease (lupus ... Bradykinin #mediated #Angioedema
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