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Antifungal Echinocandins  - Antibiotics Class Overview

Mechanism: Inhibit glucan synthesis in fungal cell wall by blocking
Anidulafungin ... Caspofungin #Micafungin #Anidulafungin
Antifungal Agents Frequently Used in Leukemia
Antibiogram:
 • Fluconazole
 • Itraconazole
 • Voriconazole
 • Posaconazole
 • Caspofungin
Caspofungin • Anidulafungin
Antifungal Coverage Activity Antibiogram 

Spectrum of action of systemic antifungal agents. Solid blocks represent species in
amphotericin; ANID = anidulafungin
Algorithm for Evaluation and Treatment of Asymptomatic Candiduria
Evidence for disseminated candidiasis, Unstable or neutropenic patient
1. fluconazole
loading → 50 mg/d 3. anidulafungin
Spectrum of activity for systemic antifungal agents
Antifungals: 5FC, flucytosine; AMB, amphotericin B; ANI, anidulafungin; CAS, caspofungin;
amphotericin B; ANI, anidulafungin
Management of Suspected and Confirmed Candida auris 

Isolate patients with suspected C auris 
 • Private
echinocandin (anidulafungin
Candida Glabrata
Species of Candida Most Commonly Isolated in Bloodstream Infections
 • Symptomatic mucosal infection is detected
, micafungin & anidulafungin
Mycoses

HISTOPLASMOSIS
• Inhalation of conidia → Yeast → travel to lymph nodes → spread in body
• Bird
micafungin, or anidulafungin