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Thrombotic Microangiopathies In Systemic Lupus Erythematosus

Dr. Laurent ARNAUD @Lupusreference

#TMAs #Thrombotic #Microangiopathies #Systemic #Lupus #Erythematosus #SLE #hematology
Erythematosus #SLE ... #hematology #rheumatology ... #differential #diagnosis ... #causes
Idiopathic Thrombocytopenic Purpura 
Clinical:
 • Gingival 
 • Menorrhagia 
 • GI bleeding 
 • Intracranial
Idiopathic Thrombocytopenic ... Corticosteroids • IVIG or anti-D ... #Purpura #Thrombocytopenia ... #Diagnosis #Overview ... #Hematology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm
 
Decreased Megakaryopoiesis
 • Aplastic Anemia
 • Toxic Damage (e.g.
Causes of Thrombocytopenia ... - Differential Diagnosis ... Autoimmune • ITP • SLE ... Alloimmune • anti-HLA ... #Hematology
Drug-Induced Thrombocytopenia
The diagnosis of drug-induced thrombocytopenia can be made only by demonstrating resolution of thrombocytopenia once
Drug-Induced Thrombocytopenia ... The diagnosis of ... are initially diagnosed ... #Diagnosis #Hematology ... #Medications #Causes
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Differential Algorithm for the Causes of thrombocytopenia 

#Diagnosis #Hematology #Thrombocytopenia #Causes #Differential
Algorithm for the Causes ... of thrombocytopenia ... #Diagnosis # ... Hematology #Thrombocytopenia ... #Causes #Differential
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
Causes of Thrombocytopenia ... - Differential Diagnosis ... test, ANA (e.g., SLE ... ), anti-phospholipid ... #hematology
I’M DAMN SHARP - Lupus Diagnosis Mnemonic
I  	 Immunoglobulins (Anti-dsDNA, Anti-Sm, Anti-phospholipid)
M 	 Malar Rash
D
SHARP - Lupus Diagnosis ... Pleuritis) H Hematologic ... #IMDAMNSHARP #sle ... erythematosus #rheumatology ... #diagnosis #mnemonic
Causes of Thrombocytopenia.
Platelet counts may be depressed because of decreased production or due to increased platelet
Causes of Thrombocytopenia ... #Diagnosis #Hematology ... #Thrombocytopenia ... #Differential #Causes
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Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
Erythematosus - Diagnosis ... Neurological 12% - Thrombocytopenia ... involvement 3% SLE-Related ... Lupusreference #SLE ... #differential #rheumatology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Differential Diagnosis ... : - Thrombocytopenia ... Splenomegaly - CTD (SLE ... Associated - SLE ... #hematology #rheumatology