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Allergic Bronchopulmonary Aspergillosis (ABPA) WHAT IS IT? Hypersensitivity response to Aspergillus fumigatus in the airways • Primarily affects
WHAT ARE THE CLINICAL ... corticosteroids +/- anti-fungal ... voriconazole) • Anti-lgE ... Aspergillosis #ABPA #pulmonary
Cryptogenic Organizing Pneumonia (COP) Cryptogenic Organizing Pneumonia Overview: • Idiopathic form of organizing pneumonia • formerly BOOP
Organizing Pneumonia - Clinical ... RF, CCP, CPK, anti-scl70 ... anticentromere ab, Anti-dsDNA ... eosinophilia pneumonia, Pulmonary ... Pneumonia #COP #BOOP #pulmonary
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
• Antibodies: Anti-Ro ... /SSA & Anti-La/SSB ... salivary ducts Clinical ... Disease: • 10%-15% Pulmonary ... , INC risk PE, Pulmonary
Hypertensive Disorders of Pregnancy Chronic Hypertension: • Guidelines as SBP ≥130 or DBP ≥ 90 mmHg •
doubling of Cr), pulmonary ... bedrest (before Anti-HTN ... or rapid ↑ in anti ... diagnosis so have high clinical
Systemic Sclerosis Associated Autoantibodies Anti-topoisomerase I (anti-Sc170): Diffuse skin disease, Pulmonary fibrosis Anti-centromere: Limited skin disease (~93-95%), Pulmonary
Autoantibodies Anti-topoisomerase ... I (anti-Sc170): ... skin disease, Pulmonary ... fibrosis Anti-centromere ... disease (~93-95%), Pulmonary
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antibodies (ANA) ANA or Anti-NucIear ... likely it will be clinically ... , Interstitial Pulmonary
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
Pulmonary Renal ... Presentation (Pulmonary ... Diagnosis for Pulmonary ... ab, anti-GBM ab ... , ANA, C3, C4, anti-CCP
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
Henoch-SchonIein Purpura Anti-GBM ... Limited to Kidney: Anti-GBM ... With associated pulmonary ... involvement: Anti-GBM
Biologic therapy for eosinophilic asthma • Mepolizumab (Nucala) • Anti-lL-5, 100 mg SQ q4
(Nucala) • Anti-lL ... Cinqair) • Anti-lL ... Fasenra) • Anti-lL ... Dupixent) • Anti-lL ... #pharmacology #pulmonary
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
Pulmonary Renal ... polyangiitis) Anti-basement ... Although pulmonary ... ANCA antibody, Anti-GBM ... usually low in anti-GBM
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