1171 results
Systemic Sclerosis Associated Autoantibodies
Anti-topoisomerase I (anti-Sc170): Diffuse skin disease, Pulmonary fibrosis
Anti-centromere: Limited skin disease (~93-95%), Pulmonary
Autoantibodies Anti-topoisomerase ... I (anti-Sc170): ... skin disease, Pulmonary ... fibrosis Anti-centromere ... disease (~93-95%), Pulmonary
Pulmonary Renal Syndrome

Definition: Diffuse alveolar hemorrhage + Glomerulonephritis
Presentation (Pulmonary and renal manifestations can occur weeks apart):
Pulmonary Renal ... Presentation (Pulmonary ... Diagnosis for Pulmonary ... ab, anti-GBM ab ... , ANA, C3, C4, anti-CCP
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
Henoch-SchonIein Purpura Anti-GBM ... Limited to Kidney: Anti-GBM ... With associated pulmonary ... involvement: Anti-GBM
Pulmonary Renal Syndromes - OnePager Summary
Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
Pulmonary Renal ... polyangiitis) Anti-basement ... Although pulmonary ... ANCA antibody, Anti-GBM ... usually low in anti-GBM
Biologic therapy for eosinophilic asthma 
• Mepolizumab (Nucala) 
  • Anti-lL-5, 100 mg SQ q4
(Nucala) • Anti-lL ... Cinqair) • Anti-lL ... Fasenra) • Anti-lL ... Dupixent) • Anti-lL ... #pharmacology #pulmonary
Pulmonary Renal Syndromes and Mimics - Differential Diagnosis Framework
Diffuse alveolar hemorrhage + rapidly progressive glomerulonephritis
90%:
 -
Pulmonary Renal ... Vasculitis - Anti-GBM ... Positive (ANCA + anti-GBM ... Kumfer @AnnKumfer #Pulmonary
Antinuclear antibodies and Systemic lupus
Anti-dsDNA	60-80%	Association with disease activity (when with Farr assay) and lupus nephritis. Can
Systemic lupus Anti-dsDNA ... when ANA+ without anti-dsDNA ... Anti-histone 60 ... neonatal lupus Anti ... -15% If SLE is clinically
Medications for High-Altitude Sickness 
Acetazolarnide 
 • Carbonic Anydrase Inhibitor Bicarb diuresis & metabolic Acidosis ->
pressure • Anti-emetic ... • Decreases pulmonary
You’ll notice there is an IgM and an IgG core antibody. The presence of IgM anti-HBc
presence of IgM anti-HBc ... IgM anti-HBc is ... presence of IgG anti-HBc ... with HBV, IgG anti-HBc ... commonly run in the clinical
Digital clubbing found in a 64 year old woman seen for pathological patellar fracture after a
#fingernails #clinical ... #photo #pulmonary