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Causes of Iron Deficiency • Inadequate Intake: Vegetarian/vegan diet, Malnutrition • Increased Body Needs: Infants/preschoolers, Pregnancy,
Causes of Iron Deficiency ... Pregnancy, EPO treatment ... surgery, PPIs, Anti-H2 ... differential #diagnosis #causes
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
10% of all lupus cases ... constitutional symptoms • Treatment ... Discontinuation of causal ... Positive in 60-80% of cases ... life-threatening • Treatment
Non-HCV infectious mixed cryoglobulinemia vasculitis - Diagnosis, causes and management - French Vasculitis Study Group < 5%
vasculitis - Diagnosis, causes ... neuropathy Treatment ... - Specific anti-infectious ... the absence of anti-infectious
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
bilirubin, ↑ LDH • Anti-RBC ... 2) LOOK FOR a cause ... diagnosis #management #treatment
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Drugs, Unknown cause ... Treatment: • ... chemotherapy, anti-CD20 ... manifestations, Anti-IFN-y ... diagnosis #management #treatment
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
10% of all lupus cases ... ) - Anti-ENA ... constitutional symptoms • Treatment ... Discontinuation of causal ... rheumatology #diagnosis #treatment
Myasthenia Gravis - Summary • an autoimmune disease of the postsynaptic neuromuscular junction associated with antibodies
- but 5% have anti—muscle-specific ... More likely to cause ... Treatment: • Symptomatic ... treatment Of ocular ... glucocorticoids - can cause
Treatment Options for Helicobacter Pylori and Peptic Ulcer Disease Active Helicobacter pylori—associated ulcer 1. Treat with anti—H pylori
Treatment Options ... Treat with anti—H ... Treatment options ... Consider other causes ... Treatment options
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
polyangiitis) Anti-basement ... ANCA antibody, Anti-GBM ... usually low in anti-GBM ... Goodpasture's cause ... diagnosis #management #treatment
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
• Antibodies: Anti-Ro ... /SSA & Anti-La/SSB ... Hypocomplementemia • Can cause ... Xerostomia • Dental caries ... Adenocarcinoma Treatment
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