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hematology differential causes management oncology thrombocytosis activetb cll generalized latenttb lymphocytic pruritus systemic tuberculosis activation hemeonc hypokalemia macrophage mas mds
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
malignancies • Anemia ... e.g. autoimmune, TB ... myeloid leukemia ... #Causes #hematology ... #secondary
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Algorithm Spurious ... Myelogenous Leukemia ... effect following treatment ... Iron deficiency anemia ... #Hematology
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
Liver Function Tests ... Creatinine & BUN: • Chronic ... • Lymphoma • Leukemia ... Pruritus #primary #secondary ... #generalized #dermatology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Chronic leukemia ... Headaches, bone pain, fever ... - infiltrates (anemia ... bone marrow and secondary ... #Diagnosis
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Chronic Lymphocytic ... minimal tumor burden Diagnosis ... ) B symptoms → fevers ... 5) Symptoms of anemia ... #hemeonc #diagnosis
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... adults in the west ... Lymphadenopathy • Fevers ... • Neutropenia, anemia ... microglobulin Treatment
Tuberculosis Overview 10 million new M. tuberculosis infections/year Facultative intracellular rod-shaped bacteria Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
• Silicosis • Chronic ... extrapulmonary Secondary ... : • Fever • Weight ... malignancy, and chronic ... #Diagnosis #Management
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
hemolysis, deficiency anemia ... Rebound effect from treatment ... • Infections: Chronic ... infections, TB, ... #Algorithm #hematology
Pruritus - No Primary Skin Lesion - Differential Diagnosis Algorithm Blood Glucose: • Diabetes Mellitus Liver Function Tests/Enzymes:
Liver Function Tests ... Creatinine & BUN: • Chronic ... • Lymphoma • Leukemia ... #Pruritus #secondary ... #generalized #dermatology
Tuberculosis Overview 10 million new M. tuberculosis infections/year Facultative intracellular rod-shaped bacteria Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
• Silicosis • Chronic ... extrapulmonary Secondary ... : • Fever • Weight ... malignancy, and chronic ... #Diagnosis #Management
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