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hematology differential causes oncology cll generalized lymphocytic management pruritus systemic thrombocytosis activation hemeonc hypokalemia macrophage mas mds myelodysplasia myelodysplastic nephrology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Algorithm Spurious ... Myelogenous Leukemia ... effect following treatment ... Iron deficiency anemia ... #Hematology
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
Liver Function Tests ... Creatinine & BUN: • Chronic ... • Lymphoma • Leukemia ... Pruritus #primary #secondary ... #generalized #dermatology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... Lymphadenopathy • Fevers ... • Neutropenia, anemia ... microglobulin Treatment ... #diagnosis #workup
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Chronic leukemia ... Headaches, bone pain, fever ... - infiltrates (anemia ... bone marrow and secondary ... #Diagnosis
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Chronic Lymphocytic ... minimal tumor burden Diagnosis ... ) B symptoms → fevers ... 5) Symptoms of anemia ... #hemeonc #diagnosis
Pruritus - No Primary Skin Lesion - Differential Diagnosis Algorithm Blood Glucose: • Diabetes Mellitus Liver Function Tests/Enzymes:
Liver Function Tests ... Creatinine & BUN: • Chronic ... • Lymphoma • Leukemia ... #Pruritus #secondary ... #generalized #dermatology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
for workup, including ... hemolysis, deficiency anemia ... Rebound effect from treatment ... • Infections: Chronic ... #Algorithm #hematology
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
in primary or secondary ... Red Flags: • Fever ... deficiency Work ... Fecal occult blood test ... #dermatology #physicalexam
Causes of Hypokalemia Transcellular Shifts: - Alkalosis, Increased plasma insulin (treatment of diabetic ketoacidosis), ß-Adrenergic agonists, Hypokalemic
plasma insulin (treatment ... hyperaldosteronism, Secondary ... , Heat stroke, Fever ... Hypomagnesemia, Acute leukemia ... #differential #diagnosis
Polycythemia - Differential Diagnosis Algorithm Polycythemia itself isn’t a diagnosis. Like many things, it is a condition
Algorithm Polycythemia ... normal/high - Chronic ... you’ll do a good workup ... Best to have an ... #Algorithm #workup
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