9 results
Causes of blood culture negative infective endocarditis

Bartonella spp, Brucella spp, Coxiella burnetii, Chlamydia spp, Tropheryma whipplei,
Causes of blood ... culture negative ... infective endocarditis ... #culture #negative ... #Endocarditis #
Blood Culture-Negative Infective Endocarditis (BCNIE)
Definition: No etiology found after 3 separate blood cultures remain negative for
Blood Culture-Negative ... Infective Endocarditis ... separate blood cultures ... but important causes ... #Infective #Endocarditis
Endocarditis Algorithm - Infective vs Noninfective Causes
Noninfective:
 • Malignancy
 • Autoimmune disease
 • Systemic infection
Native Valve
Endocarditis Algorithm ... vs Noninfective Causes ... amzn.to/2LmUODZ #Endocarditis ... #Algorithm #Infective ... #Noninfective #Causes
My Patient with Infective Endocarditis (IE) Has Negative Blood Cultures
 - Did they receive antibiotics prior
with Infective Endocarditis ... Blood Cultures ... therapy - Number one cause ... #Infective #Endocarditis ... Diagnosis #Management #Algorithm
Differentiating NBTE from Infective Endocarditis
No pathognomonic signs/symptoms or echo features that are specific to NBTE, and
from Infective Endocarditis ... serology: Serial negative ... Frequent false-negative ... /serology: + (Negative ... in up to 30% of cases
Endocarditis Summary

Who?
Infectious:
• Pre-existing valvular disease
• Prosthetic valve
• Congenital heart disease
• IV substance use
• IV catheter
• Recent
Microbiology: Blood cultures ... • Coagulase-negative ... Septic Emboli Cause ... • Blood cultures ... Treat underlying cause
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
pathophysiologic causes ... Cryoglobulinemia, Endocarditis ... Pauci-immune mediated (Negative ... differential #diagnosis #algorithm
The algorithm below shows how pre-test probability could be combined with various criteria to determine which
The algorithm below ... probability) and negative ... (~0.5%) and a negative ... Therefore, universal application ... HSV PCR would cause
Endocarditis - Overview and Differential Diagnosis Framework

Who?
Infectious:
• Pre-existing valvular disease
• Prosthetic valve
• Congenital heart disease
• IV
Endocarditis - Overview ... aureus, Coagulase-negative ... staphylococci Culture Negative ... Septic emboli cause ... Treat underlying cause