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hematology management dermatology differential oncology rash signs cellulitis cutaneous derm disease erythematosus infections infectiousdiseases leukemia lupus pathophysiology physicalexam sle symptoms
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
Clinically significant ... of peripheral blood ... cultures, including blood ... likelihood of negative clinical ... neutrophil #WBC #CBC #hematology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Internal (RBC) - Infections ... Defects: Sickle cell anemia ... - Peripheral Blood ... Smear ↑ abnormal ... #hematology
Lymphocutaneous Sporotrichiosis Infection Landscaper w/ painless nodular rash of arm present for months wax and wane; diagnosis? Lymphocutaneous
Sporotrichiosis Infection ... wax and wane; diagnosis ... trauma leads to skin ... systemic signs, labs normal ... #clinical #photo
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Clinical Presentation ... Headaches • Pale skin ... Idiopathic • Infections ... result from low blood ... #diagnosis #management
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
just beneath the skin ... petechiae) • Frequent infections ... • Parvovirus infection ... Myelodysplastic #Syndromes #diagnosis ... #hematology #oncology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Clinical Presentation ... anemia • Cold ... Immunoglobulin M (IgM) • Blood ... sensitize red blood ... #hematology #diagnosis
Janeway Lesions in Endocarditis seen on Physical Exam Dr Supradip Ghosh @dr_supradip 36 year old male with history
Blood cultures growing ... Infective Endocarditis ... could have been diagnosed ... #photo #dermatology ... #soles #skin
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome Clinical Syndrome: • Common Clinical Features: alveolitis, ear and
nose chondritis, skin ... Abnormalities: macrocytic anemia ... including peripheral blood ... myeloid cells NEJM ... Autoinflammatory #Somatic #rheumatology
Vibrio Vulnificus skin infection Cirrhosis w/recent consumption of raw oysters w/rapidly evolving rash. Vibrio vulnificus part of
Vibrio Vulnificus skin ... vulnificus part of normal ... hemochromatosis, hemolytic anemia ... Vibrio #Vulnificus #skin ... #photo
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Clinical Features ... Sjögrens (15%) Skin ... (75%): Anemia ( ... signs #symptoms #diagnosis ... #rheumatology
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