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diagnosis hematology causes pt prolonged abnormal intravascular pathophysiology adjusted algorithm anemia anticoagulant anticoagulation apixaban bleeding bruising cascade clot dabigatran ddimer
Causes of Prolonged PT (INR), Prolonged PTT • Prolonged PT (INR), Prolonged PTT • Prolonged PT
INR), Prolonged PTT ... (INR), Normal PTT ... #PPT #PT #INR #Differential ... Algorithm #Causes #Hematology ... #coagulation #disorders
Causes of Leukocytosis and Leukopenia - Differential Diagnosis • Eosinophilia (AEC > 500, hypereosinophilia > 1500):
and Leukopenia - Differential ... • Eosinopenia: Sepsis ... Neoplastic • Neutropenia ... Benign ethnic neutropenia ... Diagnosis #causes #hematology
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Abnormal PT and/or aPTT ... Congenital intrinsic coagulation ... intravascular coagulation ... Causes #diagnosis #differential ... #hematology #coagulation
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
history of trauma, sepsis ... • Prolonged PT/PTT ... PT/INR: ↑ • PTT ... INR < 2.3 - APTT ... treatment #management #hematology
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Differential Diagnosis ... the PT and the aPTT ... are both prolonged ... Causes #diagnosis #differential ... #hematology #coagulation
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
The coagulation ... multicomponent complexes are ... #Coagulation #Cascade ... thrombin #clot #PT #PTT ... diagnosis #models #hematology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
of Hemostasis - Differential ... inhibitor of a coagulation ... intravascular coagulation ... Bruising #Hemostasis #Differential ... #Diagnosis #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
intravascular coagulation ... lactam antibiotics are ... Extravascular #Causes #differential ... #diagnosis #hematology
D-dimer Plasma D-dimer is a product of clot breakdown, released upon degradation of polymerized, crosslinked fibrin. Elevated
indicate that coagulation ... increase with age ... - Age (yrs) x 10 ... pathophysiology #hematology ... #differential #
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
• Mean age at Dx ... 70-75 years of age ... Myeloproliferative Disease • Neutropenia ... blood count with differential ... Syndromes #diagnosis #hematology
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