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diagnosis hematology coagulation prolonged algorithm management aldosterone bleeding bruising dic disorders disseminated evaluation hemostasis hypoaldosteronism inr intravascular microangiopathy mixing ppt
How to Evaluate an Abnormal APTT Step 1: Is the PT or APTT Artifactually Prolonged? Step 2: Is
to Evaluate an Abnormal ... the PT or APTT ... K Antagonists, Heparin ... to identify the cause ... #diagnosis #hematology
Causes of Prolonged PT (INR), Prolonged PTT • Prolonged PT (INR), Prolonged PTT • Prolonged PT
PT (INR), Normal ... PTT, Normal PT ... , Normal PT (INR ... #INR #Differential ... #Hematology #coagulation
Approach to Thrombotic Microangiopathy (TMA) - Differential Diagnosis and Management Algorithm Suspected TMA: Unexplained thrombocytopenia + MAHA
hemoglobin/hemosiderin, Hepatic ... antiglobulin test, PT ... /aPTT MAHA likely ... hemosiderin • PT ... /aPTT normal •
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Differential Diagnosis ... PT and the aPTT ... amyloidosis #Abnormal ... #PT #aPTT #Prolonged ... #differential #
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... PT and/or aPTT ... #PT #aPTT #Prolonged ... #differential # ... hematology #coagulation
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
history of trauma, sepsis ... • Prolonged PT ... Fibrinogen: ↓ • PT ... Treat primary cause ... INR < 2.3 - APTT
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
PT/NORMAL PTT: ... PT/ABNORMAL PTT ... Acquired: • Heparin ... PT/NORMAL PTT: ... PT/ABNORMAL PTT
Etiologies of Hypoaldosteronism Hyporeninemic Hypoaldosteronism (Low Renin, Low Aldosterone) - Diabetic Nephropathy - NSAIDs Non-Hyporeninemic Hypoaldosteronism (Normal
Inhibitors - Chronic heparin ... or High Renin, Normal ... Hypoaldosteronism #Differential ... #Aldosterone #Comparison ... #Table #Causes
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
be performed PT ... , PTT, and fibrinogen ... decrease in most cases ... WBC count and differential ... Diagnosis #Workup #Hematology
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