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Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
history of trauma, sepsis ... • Prolonged PT ... Fibrinogen: ↓ • PT ... Treat primary cause ... Coagulation #diagnosis #causes
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
Differential Diagnosis ... intravascularcoagulation (DIC ... amyloidosis #Abnormal ... #differential # ... hematology #coagulation
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Causes of Abnormal ... intravascular coagulation (DIC ... Jcortesizaguirr #Abnormal ... #differential # ... hematology #coagulation
Etiologies of Hypoaldosteronism

Hyporeninemic Hypoaldosteronism (Low Renin, Low Aldosterone)
 - Diabetic Nephropathy 
 - NSAIDs
Non-Hyporeninemic Hypoaldosteronism (Normal
Inhibitors - Chronic heparin ... or High Renin, Normal ... Hypoaldosteronism #Differential ... #Aldosterone #Comparison ... #Table #Causes
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework

== Quantitative or Qualitative defect in
PT/NORMAL PTT: ... PT/ABNORMAL PTT ... Acquired: • Heparin ... PT/NORMAL PTT: ... ABNORMAL PT/
Liver Disease in Pregnancy
Intrahepatic Cholestasis of Pregnancy (ICP)
 • Onset/Trimester: 25-32 weeks
 • Typical clinical features:
imaging: Normal ... DIC • Aminotransferases ... Disease #Pregnancy #hepatology ... obstetrics #hepatitis #comparison ... #differential #
Causes of Anemia in Cirrhosis - Differential Diagnosis Framework
LOW RETIC INDEX - ↓ PRODUCTION
 • Vitamin
Causes of Anemia ... , Inflammation NORMAL ... gastric, rectal, Peptic ... Wilson's disease, DIC-low ... #Diagnosis #Hepatology
Cryofibrinogenemia Summary

Cryofibrinogenemia Epidemiology:
 • 40-70 years with a modest female predominance

Cryofibrinogenemia:
 • The precipitation of a
cooled from the normal ... cryoglobulins • Negative causes ... skin necrosis • DIC ... • Septic emboli ... #rheumatology #hematology