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diagnosis hematology causes coagulation algorithm prolonged pt anemia bruising chemistry comparison dic disseminated hemostasis hepatitis hodgkins injury interpretation intravascular lfts
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
history of trauma, sepsis ... DIC • Severe Liver ... 100mg/dL) - Heparin ... INR < 2.3 - APTT ... treatment #management #hematology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
PT/NORMAL PTT: ... PT/ABNORMAL PTT ... Acquired: • Heparin ... /NORMAL PTT: Suggests ... PT/ABNORMAL PTT
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... Early liver disease ... Reduced liver synthesis ... Causes #diagnosis #differential ... #hematology #coagulation
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Differential Diagnosis ... thrombin inhibitors, heparin ... • Reduced liver ... amyloidosis #Abnormal ... #hematology #coagulation
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Volume (MCV) - Differential ... Chronic Disease Normal ... 80-100 fL) • Bleeding ... #Anemia #MCV #Classification ... #Differential #
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
- Differential ... Injury: • Hepatic ... Venoocclusive disease • Hepatic ... RBC (hemolysis, bleeding ... diagnosis #algorithm #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
- If both are normal ... replaced by non-hepatic ... RBC (hemolysis, bleeding ... chemistry #diagnosis #differential ... #Hepatology #transaminitis
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
the spleen or liver ... translocation • Types: Classification ... also arise in normal ... Hepatosplenomegaly, cytopenias(bleeding ... #hematology
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