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diagnosis hematology management anemia blood hemolytic jaundice product algorithm bilirubinemia conjugated dermatology extravascular hodgkins intravascular lymphoma nonpalpable oncology palpable purpura
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... uremic syndrome (HUS ... Extravascular #Causes ... #differential # ... diagnosis #hematology
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Differential Diagnosis ... • MAHA: TTP, HUS ... • Transfusion reactions ... #classification ... #hematology
Classification of Jaundice Unconjugated hyperbilirubinemia (predominantly indirect bilirubin) • Increased bilirubin production (eg, hemolytic anemias, hemolytic reactions,
Classification of ... anemias, hemolytic ... reactions, hematoma ... #unconjugated #differential ... #causes
Jaundice - Differential Diagnosis Algorithm Pre-Hepatic - Unconjugated Hyperbilirubinemia Increased Production • Hemolysis • Ineffective Erythropoiesis • Hematoma Decreased
Jaundice - Differential ... Production • Hemolysis ... Hepatic Uptake • Sepsis ... Diagnosis #Algorithm #Causes ... #Hepatology #bilirubinemia
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Causes purpura & ... TRALI): Leading cause ... Occurs between 0-6 hrs ... Can lead to sepsis ... diagnosis #management #hematology
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
Causes purpura & ... TRALI): Leading cause ... Occurs between 0-6 hrs ... more likely to cause ... Can lead to sepsis
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... disease - DIC/TTP/HUS ... - Hemolytic ... : • DIC, TTP/HUS ... fever • Drug reactions
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
persons • It has ... nodosum • Immune hemolytic ... ) Classification ... Immunohistochemical studies (to differentiate ... #hematology #oncology
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