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diagnosis hematology oncology causes anesthesiology checklist hemolytic agglutinin algorithm apml chronic classification cold differentiation disease erythematosus extravascular gap globulin hemolysis
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
incompetent • CLL ... CLL Epidemiology ... CLL Labs: 1. ... • Neutropenia, anemia ... Leukemia #diagnosis #workup
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Thrombocytopenia - Differential ... Megakaryopoiesis • Aplastic Anemia ... ITP • SLE • CLL ... Non-lmmune: • HELLP Syndrome ... Algorithm #Causes #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
) - HELLP syndrome ... Hemolytic uremic syndrome ... ) (e.g. lupus, CLL ... Extravascular #Causes #differential ... #anemia
Peri-operative Hyperthermia - Guidelines for Crises in Anaesthesia If prolonged or ≥ 39 C this is a
• Sepsis (→ 3 ... • Serotonin syndrome ... #Hyperthermia #Differential ... Checklist #Diagnosis #Management ... #Workup
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Agglutinin Syndrome ... lymphoid malignancy (CLL ... malignancies -> CLL ... younger pts) Differential ... significance (MGUS), CLL
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... count (anemia) ... Workup: • Complete ... blood count with differential ... #diagnosis #hematology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Lymphoma (HCV) • CLL ... Evans • ITP • Cl-NH ... (-) hemolytic anemia ... Paraproteinemias #Hematology ... #Monoclonal #Differential
Hypotension - Guidelines for Crises in Anaesthesia Hypotension is commonly due to unnecessarily deep anaesthesia, the autonomic
causes in Box E and call ... #Hypotension #Differential ... Anesthesiology #Anesthesia ... Checklist #Diagnosis #Management ... #Workup
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... • Induce blast cell ... initiation • Differential ... APML #diagnosis #management ... #hematology #oncology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... Non-autoimmune rheumatologic ... , APLA, PAC • Aseptic ... lymphopenia, low PLT • Anemia ... La, anti-Jo-1, SCL
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