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diagnosis hepatology hepatitis acute gastroenterology lfts transaminitis aclf aih alcoholic autoimmune behcet causes chemistry cirrhosis ckd criticalcare disease drug druginduced
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Diagnosis and Management ... Injury (DILI) ... presentation • Chronic ... #differential # ... gastroenterology #algorithm
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Injury (DILI) - ... Stepwise Diagnosis Algorithm ... non-essential drug/HDS treatments ... e.g. ascites), Chronic ... #Algorithm #hepatology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... months without treatment ... Injury (DILI) ... #ACLF #Acute #Chronic ... #Cirrhosis #Hepatology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Tests (LFTs) - Differential ... Cirrhosis • Chronic ... (>1000): • DILI ... injury) • Ischemic ... #Diagnosis #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... - Differential ... Diagnosis Algorithm ... #differential # ... #hepatology
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Injury - Differential ... • Infectious: Sepsis ... #Injury #Differential ... Causes #Acute #algorithm ... #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
> 2 • NASH, Chronic ... : > 3 • Chronic ... Unconjugated Bili ... chemistry #diagnosis #differential ... #Hepatology #transaminitis
Shock - Differential Diagnosis Framework - MAP <65. SBP <90, drop in SBP > 40 -
Distributive: Sepsis ... Insufficiency, Liver ... Medications, Spinal Cord Injury ... #criticalcare #algorithm ... #treatment #management
Chronic Hepatitis B - Diagnosis and Management Algorithm • Who to treat: Essentially treat the pts with
Diagnosis and Management ... Algorithm • ... HepatitisB #HBV #Algorithm ... #Diagnosis #Management ... #Treatment #Hepatology
Autoimmune Hepatitis Clinical Presentation - Highly variable clinical presentation, from subclinical disease to acute liver failure. -
disease to acute liver ... - Symptoms of chronic ... injury, though ... regarding need for treatment ... #Hepatology
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