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diagnosis causes hepatology peds lfts transaminitis acidosis alte brue chemistry classification dims drug druginduced elderly elevation epilepsy event function gastroenterology
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Injury (DILI) ... dose dependent injury ... #differential # ... gastroenterology #algorithm ... gastroenterology #hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Injury (DILI) - ... Stepwise Diagnosis Algorithm ... involvement, Kidney injury ... dechallenge • Acute ... #Algorithm #hepatology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Tests (LFTs) - Differential ... Hepatopathy • Acute ... (>1000): • DILI ... injury) • Ischemic ... #Diagnosis #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... - Differential ... Diagnosis Algorithm ... Liver Injury: ... #hepatology
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Causes of Acute ... Liver Injury - Differential ... • Infectious: Sepsis ... #Injury #Differential ... #algorithm #hepatology
Causes of Provoked Pediatric Seizures - Differential Diagnosis Algorithm - "DIMS" Mnemonic Drugs: • Drug overdose •
Causes of Provoked Pediatric ... Seizures - Differential ... Diagnosis Algorithm ... • Sepsis • ... Structural: • Head Injury
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
injury < 26 weeks ... Unconjugated Bili ... > 90% of Total Bili ... chemistry #diagnosis #differential ... #Hepatology #transaminitis
Causes of Pediatric Seizures - Differential Diagnosis Algorithm Infantile: • Benign Focal Epilepsy of Infancy • West
Causes of Pediatric ... Seizures - Differential ... Diagnosis Algorithm ... • Sepsis • ... Structural: • Head Injury
Causes of Sudden Unexpected Death in Infancy (SUDI) - Differential Diagnosis Algorithm Congenital Anomaly / Disorder: •
Diagnosis Algorithm ... Pneumonia • Sepsis ... Gastrointestinal infection Injury ... Accidental* Other: • Acute ... #Causes #Peds #Pediatrics
Causes of Apparent Life Threatening Event (ALTE) - Differential Diagnosis Algorithm Cardiac: • Congenital Heart Disease •
Diagnosis Algorithm ... Neurologic: • Seizure ... Pneumonia • Sepsis ... Choking Spell Injury ... #Causes #Peds #Pediatrics
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