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Heparin Induced Thrombocytopenia (HIT) - Diagnosis and Management - GrepMed Handbook

Presentation: 
 • Plts ↓50% (nadir
Factors: • SICU ... > MICU, ♀, ↑Age ... → Calculate 4T score ... • If 4T score ... #Treatment #Hematology
Our approach to the diagnosis and initial management of patients with suspected HIT. Our approach is
diagnosis and initial management ... primarily on clinical assessment ... and to adjust treatment ... #Hematology #HIT ... #Heparin #Induced
Hemophilia - Diagnosis and Management
Diagnosis:
 • Consistent bleeding history (unless screening for disease in family members
Diagnosis and Management ... - Acute Bleeding ... Avoid meds that ... though safety assessment ... #treatment #hematology
Hepatitis B - Treatment Indications
Treatment not indicated:
 • Immune tolerant state - HBe-Ag detectable, high HBV
Hepatitis B - Treatment ... immunosuppression • Acute ... > 3 mg/dL) or acute ... #Indications #management ... #hepatology
Non-alcoholic fatty liver disease algorithm.
 
For those patients with NAFLD or liver disease of unknown aetiology,
Initial assessment ... NAFLD fibrosis score ... with values <1.3 ... algorithm #Referral #Management ... #Hepatology
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
- ACS, AKI, acute ... priapism • Lab values ... sudden death • Lab values ... TLS #diagnosis #management ... #hematology
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Triggers: ATRA treatment ... Renal Failure Treatment ... organ dysfuxtion, ICU ... APML #diagnosis #management ... #hematology #oncology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
malignancy (Especially acute ... + Bleeding Treatment ... 100mg/dL) - Heparin ... diagnosis #causes #treatment ... #management #hematology
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
+ Etiological Assessment ... +++ (Plt, Hb), Hepatic ... of emergency, ICU ... Lymphohistiocytosis #diagnosis #management ... #rheumatology
Nutrition in Cirrhosis: Dos and Don’ts
Screening:
 • Patients at risk for RFH-Nutritional Prioritizing Tool
 • Low
disease (Child-Pugh score ... C) Assessment: ... prevent or treat hepatic ... Cirrhosis #diet #management ... #hepatology #pathophysiology