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Heparin Induced Thrombocytopenia (HIT) - Diagnosis and Management - GrepMed Handbook

Presentation: 
 • Plts ↓50% (nadir
Heparin Induced ... → Calculate 4T score ... • If 4T score ... #HIT #Heparin #Induced ... #Treatment #Hematology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines

ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... months without treatment ... Hepatitis (AAH) Drug-Induced ... Failure #Cirrhosis #Hepatology ... gastroenterology #management
Our approach to the diagnosis and initial management of patients with suspected HIT. Our approach is
diagnosis and initial management ... primarily on clinical assessment ... and to adjust treatment ... #Hematology #HIT ... #Heparin #Induced
Clinical diagnosis of Alcoholic Hepatitis (AH)
 • Onset of jaundice within prior 8 weeks
 • Ongoing
>1.5, and both values ... Possible drug-induced ... Uncertain alcohol use assessment ... ., AST or >400 IU ... Hepatitis #AH #hepatology
Hemophilia - Diagnosis and Management
Diagnosis:
 • Consistent bleeding history (unless screening for disease in family members
Diagnosis and Management ... - Acute Bleeding ... Avoid meds that ... though safety assessment ... #treatment #hematology
Hepatitis B - Treatment Indications
Treatment not indicated:
 • Immune tolerant state - HBe-Ag detectable, high HBV
Hepatitis B - Treatment ... immunosuppression • Acute ... > 3 mg/dL) or acute ... #Indications #management ... #hepatology
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Triggers: ATRA treatment ... endothelial damage • Induce ... organ dysfuxtion, ICU ... APML #diagnosis #management ... #hematology #oncology
Clinical Diagnosis of Autoimmune Hepatitis
 - Onset of jaundice within prior 8 weeks
 - Ongoing consumption
>1.5, and both values ... Possible drug-induced ... Uncertain alcohol use assessment ... ., AST or >400 IU ... Hepatitis #Diagnosis #Hepatology
Non-alcoholic fatty liver disease algorithm.
 
For those patients with NAFLD or liver disease of unknown aetiology,
Initial assessment ... NAFLD fibrosis score ... with values <1.3 ... algorithm #Referral #Management ... #Hepatology
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
- ACS, AKI, acute ... priapism • Lab values ... sudden death • Lab values ... TLS #diagnosis #management ... #hematology