24 results
Wernicke Encephalopathy - Acute Thiamine (B1) Deficiency 
Clinical Diagnosis - Caine Criteria (2 out of 4):
Wernicke Encephalopathy ... Thiamine (B1) Deficiency ... dysfunction and gait ... ataxia is only ... @gabifpucci #Wernicke
Wernicke's Encephalopathy vs Korsakoff Syndrome - Thiamine Deficiency

Wernicke's encephalopathy is a neurological condition due to longstanding
Syndrome - Thiamine Deficiency ... thiamine (vitamin B1) deficiency ... of confusion, ataxia ... (broad-based gait ... #B1 #thiamine #deficiency
Wernicke Encephalopathy - Acute B1 (Thiamine) Deficiency - Diagnosis and Management
Diagnosis - Caine Criteria (2 of
Wernicke Encephalopathy ... dysfunction (e.g. gait ... ataxia - usually ... thiamine can worsen Wernicke ... @neudrawlogy #Wernicke
Wernicke Encephalopathy - Triad

Encephalopathy 
 • Disorientation 
 • Indifference 
 • Inattentiveness 
Ocular motor dysfunction
Wernicke Encephalopathy ... gaze palsies Ataxia ... • Gait • ... Stance #Wernicke ... Neurology #Thiamine #Deficiency
Thiamine Deficiency - Differential Diagnosis Framework and Clinical Manifestations

Causes of Thiamine Deficiency:
 • Poor intake:
	- Diets
Thiamine Deficiency ... Syndrome: • Wernicke's ... Ophthalmoplegia - Ataxia ... beriberi #nutrition #pathophysiology ... #wernickes #korsakoff
Clinically Important Vitamins and Vitamin Deficiency States
Fat-soluble Vitamins: 
 • Vitamin A - Xerophthalmia, night blindness,
Vitamins and Vitamin Deficiency ... Haemolytic anaemia, ataxia ... B1 - Beri-beri, Wernicke-Korsakoff ... #Vitamins #Deficiency
Wernicke's Encephalopathy 
CLINICAL TRIAD: only seen in 1/4 pts 
W.E. is often under diagnosed 
1. ENCEPHALOPATHY
Wernicke's Encephalopathy ... GAIT ATAXIA (23% ... Primarily: Stance & gait ... no upper limb ataxia ... vestibular #Wernickes
Causes of Gait Disturbance - Differential Diagnosis Algorithm
Sporadic
 • Vascular
 • Infection
 • Toxic
 • Nutrition
Causes of Gait Disturbance ... • Friedrich's Ataxia ... Childhood Catalytic Deficiency ... Childhood Catalytic Deficiency ... Niemann-Pick Disease #Gait
Anticonvulsants as Mood Stabilizers: Mechanism and Side-effect
Examples: Valproate, Carbamazepine, Lamotrigine
 • Mild anticholinergic effect -> Drowsiness
Dose-dependent tremor, ataxia ... dizziness, diplopia, ataxia ... pruritus, weight gain ... #SideEffects #Pathophysiology
Micronutrient Deficiencies After Gastric Bypass
Fat-Soluble Vitamins:
 • Vitamin A - Night/complete blindness, xeropthalmia (pathologic dryness of
and vomiting, Wernicke's ... oculomotor dysfunction, gait ... ataxia), Korsakoff ... sensory neuropathy, ataxia