2010 results
Causes of Vitamin B12 Deficiency - Cobalamin
Decreased Intake
Pancreas: Insufficiency
Intestine: SIBO, Celiac disease, IBD, Lymphoma, Amyloidosis, Resection,
Causes of Vitamin B12 ... : SIBO, Celiac disease ... pylori infection, B12 ... BrighamChiefs #Vitamin #B12
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Normal Blood Smear
 •
- Low Serum B12 ... - Low Serum B12 ... • Pancreatic Disease ... • Rule out B12 ... • Liver Disease
Dizziness - Differential Diagnosis Framework
"Tell me what you mean by dizzy without using the word dizzy."
Vertigo:
Neuritis, Meniere's Disease ... Cardiac: Valvular Disease ... neuropathy (DM, B12 ... Dysfunction: Parkinson's disease ... Coordination/Strength: B12
Demyelinating Diseases - Differential Diagnosis
 • Inflammatory: MS, ADEM, NMO, Paraneoplastic, Sjogren's, Polyarteritis nodosa, SLE
 •
Demyelinating Diseases ... Other: Vitamin B12 ... Demyelinating #Diseases
Causes of Low Vitamin B12 Levels
Low vitamin B12 intake - Vegetarianism, chronic alcoholism and older people
Autoimmune
of Low Vitamin B12 ... Levels Low vitamin B12 ... insufficiency, Crohn 's disease ... , coeliac disease
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Low Mean Corpuscular Volume (<80
Anemia of Chronic Disease ... Anemia of Chronic Disease ... Renal Disease, Liver ... Disease, Endocrinopathy ... (>100 fL) • B12
Red Blood Cell (RBC) Morphology
Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
anemia, Chronic disease ... Macrocytic RBC: Vitamin B12 ... deficiency, Liver Disease ... Uremia, Liver disease ... Hemoglobin SS disease
Anemia - Underproduction Diagnostic Algorithm
 - Iron deficiency anemia
 - Anemia of chronic inflammation
 - Anemia
chronic kidney disease ... - Vitamin B12
Metformin in Diabetic Kidney Disease
Immediate release:
 • Initial 500 mg or 850 mg once daily
 •
Diabetic Kidney Disease ... Monitor vitamin B12 ... risk of vitamin B12
Pancytopenia - Differential Diagnosis

Congenital Diseases:
• GATA2 deficiency
• Fanconi’s anemia
• Wiskott-Aldrich syndrome
• Ribosomopathy or telomeropathy

Cancer:
• Leukemia
• Lymphoma

Inflammatory
Congenital Diseases ... and Autoimmune Diseases ... consumption • Vitamin B12