23 results
Type I Hypersensitivity: Pathogenesis and clinical findings
Definition: Production of lgE Antibodies that bind to harmless allergens
Antibodies that bind ... leading to an allergic ... reaction. ... complexes bind ... histamine) into the blood
Hypersensitivity: Definitions
 • Type I - Production of lgE Abs that bind to harmless allergens and
of lgE Abs that bind ... cell surfaces causes ... causes development ... An allergic reaction ... #Allergic #Reactions
Basophilia - Differential Diagnosis Framework

Basophils < 1% of the total white blood cell count
Basophils function similarly
the total white blood ... released during an allergic ... reaction or asthma ... Or Inflammatory Reactions ... #hematology #basophils
Summary table of types of hypersensitivity reactions. 
Type 1
 - Mediators: lgE
 - Antigen Form: Soluble
hypersensitivity reactions ... Mechanism of Action: Allergen-specific ... lgE causes mast-cell ... lgM antibodies bind ... #types #allergy
Eosinophil Disorders Testing Algorithm
INDICATIONS FOR TESTING:
 • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
• Peripheral blood ... for secondary causes ... eosinophilia (common causes ... are asthma, allergy ... , drug reaction,
Drug Reaction with Eosinophilia and Systemic Signs (DRESS Syndrome): Formerly known as drug hypersensitivity reaction, DRESS
represents
Drug Reaction with ... hypersensitivity reaction ... associated with allergic ... (in this case Tegretol ... Images #Clinical #Dermatology
Drug Reaction with Eosinophilia and Systemic Signs (DRESS Syndrome): Formerly known as drug hypersensitivity reaction, DRESS
represents
Drug Reaction with ... hypersensitivity reaction ... associated with allergic ... (in this case Tegretol ... Images #Clinical #Dermatology
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
lgE antibodies bind ... When the specific allergen ... - Red blood cell ... with mismatched blood ... #Diagnosis #Reactions
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
→ Refer to hematology ... hematologic: Acute blood ... syndrome, POEMS • Reaction ... post-splenectomy, Exercise, Allergic ... reactions Matthew
Blood Transfusion Reactions

Immune Mediated:
 • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Allergic reaction ... Causes purpura & ... TRALI): Leading cause ... more likely to cause ... diagnosis #management #hematology