17 results
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Differential Diagnosis ... Splenomegaly - CTD (SLE ... Vasculitis: • Hypersensitivity ... Associated - SLE ... #hematology #rheumatology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
) - Diagnosis and ... Management Summary ... Positive in 60-80% of cases ... Erythematosus #Diagnosis ... #rheumatology
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... activity that bind ... vasculitis • Hypersensitivity ... #types #classification ... #rheumatology #
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
Discontinuation of causal ... Usual therapeutic management ... #comparison #table ... #rheumatology # ... diagnosis #management
Summary table of types of hypersensitivity reactions. 
Type 1
 - Mediators: lgE
 - Antigen Form: Soluble
table of types of hypersensitivity ... Allergen-specific lgE causes ... lgM antibodies bind ... allergy #table #classification ... #comparison
Lupus Nephritis Primer
Class I - Minimal Mesangial
Class II - Mesangial Proliferative
Class Ill - Focal Proliferative
Class IV
Lupus #Nephritis #SLE ... #Classification ... #Classes #differential ... #diagnosis #management
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE ... autoantibodies that will cause ... Erythematosus #SLE ... CNS #neurology #rheumatology ... #management #treatment
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Auto-amplification loop Diagnosis ... Autoimmune diseases: SLE ... Drugs, Unknown cause ... #management #treatment ... #summary #rheumatology
Hypersensitivity: Definitions
 • Type I - Production of lgE Abs that bind to harmless allergens and
Hypersensitivity ... of lgE Abs that bind ... cell surfaces causes ... Reactions #Types #Classification ... #Diagnosis #Definitions
Hodgkin's Lymphoma Overview

Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
) Classification ... lymph node biopsy (diagnostic ... #classification ... #hematology #oncology ... #management