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diagnosis differential cirrhosis rheumatology activation algorithm alkphos arterial astalt biliary chemistry cholangitis congenital dermatology embolism gastroenterology hemolysis hepatitis hepatopulmonary hps
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism AST and ALT: • AST: liver
Liver Chemistry ... Phosphatase and Bilirubin ... mitochondria (mAST ... initial insult Bilirubin ... #Hepatology #Pathophysiology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
AIHA, Transfusion reactions ... Drug-associated, PCH, Evans Syndrome ... Defects, Drugs, Liver ... - Unconjugated Bilirubin ... Differential #Diagnosis #hematology
Portal Hypertension - Differential Diagnosis Portal Pressure = the pressure difference between the pressure in the portal
and hepatorenal syndrome ... function: INR, bilirubin ... • Budd Chiari syndrome ... sarcoidosis) • Liver ... #hepatology
Inherited Non-hemolytic Disorders of Hyperbilirubinemia == Disorders of Conjugation == Gilbert Syndrome: • 5-10% of the population
Conjugation == Gilbert Syndrome ... hyperbilirubinemia syndrome ... of hemolysis or liver ... and stress may cause ... #hepatology #diagnosis
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Algorithm Vascular Causes ... vein: Budd-chiari syndrome ... week • Direct bilirubin ... • Gilbert's syndrome ... diagnosis #algorithm #hepatology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Kasabach-Merritt syndrome ... deficiency • Liver ... Gardner-Diamond syndrome ... fever • Drug reactions ... Differential #Diagnosis #hematology
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
65 years PBC Pathophysiology ... intralobular bile ducts causes ... slightly elevated • Bilirubin ... or higher • Liver ... diagnosis #workup #hepatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
(MAS) Classified ... manifestation of MAS ... thrombocytopenia • Liver ... ↑ AST ↑ ALT ↑ bilirubin ... Diagnosis #Management #Hematology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
• Nephrotic Syndrome ... , Ischemic Liver ... coagulation and other causes ... Venous #Arterial #pathophysiology ... #hematology #differential
Hepatopulmonary Syndrome - Illness Script HPS is a pulmonary disorder of chronic liver disease characterized by a
Hepatopulmonary Syndrome ... abnormalities PATHOPHYSIOLOGY ... arteriovenous shunting causes ... mixed blood to pass ... cirrhosis #diagnosis #hepatology
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