10 results
Adult-Onset Still's Disease
Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia
+ Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Adult-Onset Still's ... Disease Clinical ... Arthralgia/arthritis, Skin ... #diagnosis #management ... #treatment #rheumatology
Blood Transfusion Reactions

Immune Mediated:
 • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
resembles ARDS, onset ... infections with skin ... Borrellia (Lyme disease ... Transfusion #diagnosis #management ... #hematology #reactions
Blood Product Transfusions One Pager Summary
Type and screen - determines blood type and detects in recipient
resembles ARDS, onset ... infections with skin ... Borrellia (Lyme disease ... Transfusions #diagnosis #management ... #hematology #reactions
Adult Onset Still's Disease
Systemic inflammation with urticarial rash.
Rash: 
 • Nonpruritic, evanescent (correlates with time of
Adult Onset Still's ... fever - Fever spikes ... maculopapular skin ... #onset #Stills ... #management
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Phagocytosis of blood ... • Autoimmune diseases ... : SLE+++, Adult-onset ... Still disease, ... Lymphohistiocytosis #diagnosis #management
Adult Onset Still's Disease - Yamaguchi Criteria
Major criteria:
 - Fever >= 39C lasting >= 1 weeks
Adult Onset Still's ... Disease - Yamaguchi ... weeks - Typical skin ... concomitant fever spikes ... #Major #Minor #Rheumatology
Blanching Spider Angioma (Nevus) on Physical Exam

Spider angiomas are usually benign but often can be suggestive
underlying systemic disease ... in 15% of young adults ... just beneath the skin ... PhysicalExam #clinical #video ... #dermatology #skin
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Purpura, ischemic skin ... , drug reactions ... pulses, bruits, or blood ... Nervous System: • Onset ... Differential #Diagnosis #Rheumatology
Monkeypox

What?
Monkeypox virus belongs to the family Poxviridae, subfamily Chordopoxvirinae, and genus orthopoxvirus
Viral zoonotic disease that is
Viral zoonotic disease ... both children and adults ... days after the onset ... Polymerase chain reaction ... MPOX #Diagnosis #Management
Autoimmune Myositis - Differential Diagnosis Framework

Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
) • Anti-Mi2 (skin ... cancer-associated adult ... ALS • Very slow onset ... forward of the spine ... Myositis #Myopathy #rheumatology