16 results
Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
Systemic Lupus Erythematosus ... Auto-Antibodies: - ANA ... #Diagnosis #autoantibodies ... #signs #symptoms ... #differential #rheumatology
Antinuclear antibodies and Systemic lupus
Anti-dsDNA	60-80%	Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... #autoantibodies ... Systemic #lupus #erythematosus ... #diagnosis #rheumatology ... #table #ANA
Inflammatory Myopathies
Dermatomyositis
 • Onset: Subacute
 • Pattern: Proximal
 • CK: Up to 50X ULN
 • Autoantibodies:
heliotrope, shawl sign ... Pattern: Proximal and ... #differential #diagnosis ... #comparison #rheumatology ... #table
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
lgE antibodies bind ... Type Ill - IgG and ... systemic lupus erythematosus ... Pathophysiology #Allergy #Diagnosis ... #Reactions #Table
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... context of other symptoms ... @AnnKumfer #Antinuclear ... #patterns #rheumatology ... #diagnosis #differential
Scarlet fever
• Delayed-type skin reactivity to pyrogenic exotoxin Requires prior exposure
• Diffuse erythematous eruption that generally
fever • Delayed-type ... exposure • Diffuse erythematous ... Scarlet #fever #diagnosis ... clinical #photo #signs ... #symptoms
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
• Anti-Ro/SSA autoantibodies ... Differential Diagnosis ... Kikuchi disease • Type-I ... Induced Lupus: • Symptoms ... #Diagnosis #Rheumatology
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
activity that bind ... Labs/Diagnosis: ... systemic lupus erythematosus ... Cryoglobulins #diagnosis ... #rheumatology #
Pemphigus Vulgaris vs Bullous Pemphigoid - Comparison Table
Pemphigus Vulgaris
 • Epidemiology: Average age 40-60
 • Time
Pemphigoid - Comparison Table ... , relapsing • Symptoms ... ruptured • Nikolsky sign ... • Antibodies: Autoantibodies ... Pemphigoid #Comparison #diagnosis
Features That Differentiate Acute Pericarditis from Myocardial Ischemia or Infarction and Pulmonary Embolism

In contrast to the
systemic lupus erythematosus ... #Pericarditis #Symptoms ... #Signs #Presentation ... #comparison #Table ... #Diagnosis