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hematology differential antinxp2 antinxp2dm bullous coagulation dermatomyositis dic disseminated hemeonc hemophagocytic hlh intravascular leukostasis lymphohistiocytosis lysis myelitis naildisorders neurology pemphigoid
Nail Disorders secondary to Systemic Diseases Nail Fold Abnormality • SLE • Scleroderma • Dermatomyositis Koilonychia - Spoon-shaped
Spoon-shaped • Iron deficiency ... malnutrition) Blue ... Systemic #Secondary #dermatology ... #Differential #Diagnosis ... #Algorithm #causes
Bullous Pemphigoid - Diagnosis and Management Summary Pathophysiology: Autoantibody-mediated damage to epithelial basement membrane -> separation of
Bullous Pemphigoid - Diagnosis ... Summary Pathophysiology ... dermis Clinical Signs ... - Erosions and crusts ... #Management #dermatology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... high WBC count cause ... WBC >100k, + lab signs ... Syndrome #TLS #diagnosis ... #management #hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
protein C and S Pathophysiology ... thrombopoietin deficiency ... #Coagulation #diagnosis ... #causes #treatment ... #management #hematology
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
monophasic Pathophysiology ... bouts of HTN Diagnostic ... • Bilateral signs ... • Nutritional Deficiency ... #management #neurology
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
Periorbital heliotrope (blue-purple ... chest (in a V-sign ... Muscle atrophy may cause ... #management #rheumatology ... #dermatology
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
recognition and management ... hyperinflammatory syndrome caused ... Presentation • Common Signs ... Pathophysiology ... #Management #Hematology
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