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causes liver hematology transaminitis anemia management workup acute classification diarrhea endocrinology gastroenterology hepatitis polycythemia thrombocytosis abnormal aclf aki approach chemistry
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
presentation • Chronic ... - ongoing ↑ LFTs ... symptoms of liver disease ... Idiosyncratic #differential ... gastroenterology #algorithm
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
) - Differential ... Cirrhosis • Chronic ... (>1000): • DILI ... Drug-induced liver injury ... Diagnosis #hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Diagnosis Algorithm ... Alcohol-related liver disease ... e.g. ascites), Chronic ... #Diagnosis #Algorithm ... #hepatology
Anemia - Underproduction Diagnostic Algorithm - Iron deficiency anemia - Anemia of chronic inflammation - Anemia
Algorithm - Iron ... kidney disease ... disorder - TSH, LFTs ... #hematology #diagnosis ... #differential #
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
- Differential ... Diagnosis Algorithm ... • Iatrogenic: DILI ... #diagnosis #algorithm ... #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... : > 3 • Chronic ... liver #chemistry #diagnosis ... #differential # ... Hepatology #transaminitis
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
underlying liver disease ... Drug-Induced Liver Injury ... (DILI) Viral Hepatitis ... Failure #Cirrhosis #Hepatology ... gastroenterology #management #diagnosis
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
Differential Diagnosis ... HELLP, Celiac disease ... Diagnosis #hepatology ... #algorithm #Transaminitis ... #LFTs #hepatitis
Non-ACS Myocardial Injury - Elevated Troponin Differential Diagnosis and Workup Algorithm • Chronic Myocardial Injury: End
Diagnosis and Workup ... Algorithm • ... Chronic Myocardial ... Renal Disease, ... #Diagnosis #Algorithm
Chronic Diarrhea - Differential Diagnosis Algorithm Steatorrhea - Maldigestive • Pancreatic Insufficiency - Primary
Chronic Diarrhea ... - Differential ... Diagnosis Algorithm ... #Differential # ... Diagnosis #Algorithm
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