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diagnosis differential transaminitis causes dili hepatitis abnormal acute chemistry drug druginduced function gastroenterology hepatocellular idiosyncratic induced interpretation liverenzymes management rvalue
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Tests (LFTs) - ... 100-500): • NAFLD ... Cirrhosis • Chronic ... injury) • Ischemic ... Differential #Diagnosis #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... ALT < 5x ULN • NAFLD ... • Cholestatic disease ... • Others #LFTs ... #Hepatology #LiverEnzymes
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
Injury → liver ... antitrypsin • Other: NAFLD ... #Diagnosis #hepatology ... #algorithm #Transaminitis ... #LFTs #hepatitis
Abnormal liver function tests algorithm. This figure details the initial response to abnormal liver blood tests.
tests algorithm ... disease; T2DM, ... #LFTs #Abnormal ... #Algorithm #Hepatology ... #Liver #Enzymes
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
presentation • Chronic ... - ongoing ↑ LFTs ... disease 6-9 mo ... gastroenterology #algorithm ... gastroenterology #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... disease: > 2 ... • NASH, Chronic ... Enzyme Elevation ... #differential #Hepatology
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Injury - Differential ... Antitrypsin • Other: NAFLD ... #Injury #Differential ... Causes #Acute #algorithm ... #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... Differential Diagnosis Algorithm ... • NASH, Chronic ... Enzyme Elevation ... #hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Stepwise Diagnosis Algorithm ... disease, Hepatic ... dechallenge • Acute or chronic ... e.g. ascites), Chronic ... #Algorithm #hepatology
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