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diagnosis differential infectiousdiseases treatment hemophagocytic hepatology lymphohistiocytosis workup comparison diarrhea fluid fungal hepatitis oncology reactions rheumatology 1 5asa activation acute
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Triggering factor (infection ... Phagocytosis of blood ... : • Infections ... Still disease, Infection ... Etiological+++: Anti-infectious
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
can mimic common infections ... Splenomegaly • Low ... Treatment: • Infection ... Lymphohistiocytosis #diagnosis #management ... #treatment #hematology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
hypogammaglobulinemia -> increased infection ... history of recurrent infections ... disease • Infectious ... community-acquired infections ... Malignancies • Chronic infections
Algorithm for the Evaluation of Acute Diarrhea (< 7 days) Are the following present? 1.
Algorithm for the ... Ova and parasite ... HIV infection or ... Bloody diarrhea, ... #management #algorithm
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
Blood Product Transfusions ... Blood products contain ... • Infection - ... Infection occurs ... likely to cause infections
Algorithm for the Evaluation of Chronic Diarrhea (< 7 days) Exclude: 1. Causes of acute diarrhea 2. Lactose intolerance 3.
Algorithm for the ... Causes of acute diarrhea ... Parasitic infections ... leukocytes and occult blood ... #management #algorithm
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Blood products contain ... Hypothermia: Due to low ... Infection - Infection ... likely to cause infections ... #diagnosis #management
Persistent UC Symptoms Despite 5-ASA Therapies • Assess for Drug Adherence • Disease Activity Assessment (bloody
diarrhea correlates ... diarrhea) • FCP ... Colonoscopy • Rule-Out Infection ... Refractory #Treatment #Management ... #Algorithm
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
inflammatory disease How ... SLE], AOSD) • Infection ... Fibrin degradation products ... Syndrome #Diagnosis #Management ... #Hematology #Rheumatology
Deciphering the SAAG - Serum to Ascites Albumin Gradient Ascites is either made in the liver sinusoid
albumin in the blood ... albumin to escape blood ... • Produced by a ... oncotic pressure Low ... source: Malignancy, Infection
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