118 results
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
• Autoimmune diseases ... Adult-onset Still disease ... Treatment: • ... Lymphohistiocytosis #diagnosis #management ... #treatment #summary
Classification, Differential Diagnosis, and Features of Hyponatremia According to Volume Status 

Hypervolemic hypernatremia 
 - CHF
Classification, ... chronic kidney disease ... Vomiting - Diarrhea ... #Hyponatremia #Classification ... Diagnosis #Table #Causes
Hemophagocytic Lymphohistiocytosis (HLH) Treatment
Primary HLH:
 - HLH-94 Protocol
    • Dexamethasone
) Treatment Primary ... or autoimmune disease ... , treatment of underlying ... for refractory disease ... #Treatment #management
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Lymphohistiocytosis (HLH ... age, however the disease ... • Bicytopenia Treatment ... Lymphohistiocytosis #diagnosis #management ... #treatment #hematology
Leptospirosis
Pathogen: Leptospira (interrogans, kirschneri, noguchii)
Risk Factors:
 • Occupational exposure - Farmers, ranchers, trappers, veterinarians
 • Recreational
non-productive cough, nausea ... , vomiting and diarrhea ... Severe pulmonary disease ... microbiology #diagnosis #treatment ... #management
Persistent UC Symptoms Despite 5-ASA Therapies
 • Assess for Drug Adherence
 • Disease Activity Assessment (bloody
Drug Adherence • Disease ... Assessment (bloody diarrhea ... UC > non-bloody diarrhea ... Escalate Treatment ... #Management #Algorithm
Angioedema - Classification Diagnosis and Treatment
Types of Angioedema:
 • Acute allergic angioedema - Usually occurs with
Angioedema - Classification ... dominant inherited disease ... dominant inherited disease ... cell-mediated in > 90% of cases ... #management #allergy
Lyme Disease Pearls

Epidemiology: Ixodes scapularis carrying borrelia 
have spread and are now found in 
growing areas
Lyme Disease Pearls ... Quebec, Montreal, Nova ... Slovenia) Treatment ... : TREATMENT Shorter ... #Diagnosis #Management
Algorithm for the Evaluation of Chronic Diarrhea (< 7 days)
Exclude:
1. Causes of acute diarrhea
2. Lactose intolerance
3.
Evaluation of Chronic Diarrhea ... Causes of acute ... diarrhea 2. ... Systemic disease ... #management #algorithm
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
lymphohistiocytosis (HLH ... highly inflammatory disease ... hypersensitivity syndromes • HLH ... Treatment: • Corticosteroids ... Syndrome #Diagnosis #Management