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diagnosis rheumatology classification management comparison complications cryoglobulinemia cryoglobulins differential druginduced erythematosus mucocutaneous pathophysiology signs summary symptoms systemic table types vasculitides
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
1 • Clinical Manifestations ... Alopecia, oral ulcers ... • Laboratory Manifestations ... Positive in 60-80% of cases ... Management #Summary #rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
vs SLE Drug Induced ... cases, drug-dependent ... Discontinuation of causal ... Alopecia, oral ulcers ... #table #rheumatology
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Lupus (SLE): Mucocutaneous ... Manifestations ... hair follicles -> causes ... > Mouth, Nasal Ulcers ... Livedo Reticularis, Vasculitis
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... livedo reticularis, ulcers ... genital aphthous ulcers ... such as systemic lupus ... , and SLE) • Urinalysis
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Purpura - Skin ulcers ... Cryoglobulins Cause ... (e.g. systemic lupus ... erythematosus (SLE
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