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diagnosis differential dermatology systemic generalized oncology pruritus cd4 chronic common cvid elevatedmcv fatigue hypogammaglobulinemia icl idiopathic immunodeficiency immunology leukemia lymphocytopenia
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... DDX: Rule Out Secondary ... Causes • Anemia ... Workup: • Complete ... #hematology #oncology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Causes of Thrombocytosis ... malignancies • Anemia ... vera (PV) • Myelodysplastic ... syndrome • Myelofibrosis ... #hematology #secondary
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Causes of Anemia ... Differential Diagnosis Algorithm ... Hypersplenism • Secondary ... RA, SLE, PRV, Chronic ... #Causes #Hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... Differential Diagnosis Algorithm ... Dysplastic • Myelodysplastic ... Syndromes Macrocytosis ... #Causes #Hematology
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
renal failure/uremia ... Throbocythemia • Myelodisplastic ... syndrome Psychiatric ... Pruritus #primary #secondary ... #causes
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Causes of Thrombocytopenia ... Megakaryopoiesis • Aplastic Anemia ... Autoimmune • ITP • SLE ... Non-lmmune: • HELLP Syndrome ... #Causes #Hematology
Nail Disorders secondary to Systemic Diseases Nail Fold Abnormality • SLE • Scleroderma • Dermatomyositis Koilonychia - Spoon-shaped
Nail Disorders secondary ... Abnormality • SLE ... • Nephrotic syndrome ... #Diagnosis #Algorithm ... #causes
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
leakage of RBC's secondary ... - Hemolytic anemia ... Splenomegaly - CTD (SLE ... Kasabach-Merritt syndrome ... Associated - SLE
Causes of Fatigue - Differential Diagnosis Algorithm Endocrine • Hypo/Hyperthyroidism • Diabetes • Pituitary Insufficiency • Adrenal
Causes of Fatigue ... Neoplastic / Hematologic ... • Anemia • ... Arthritis • SLE ... Chronic Fatigue Syndrome
Pruritus - No Primary Skin Lesion - Differential Diagnosis Algorithm Blood Glucose: • Diabetes Mellitus Liver Function Tests/Enzymes:
renal failure/uremia ... Throbocythemia • Myelodisplastic ... syndrome Psychiatric ... #Pruritus #secondary ... #causes
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