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diagnosis hematology management leukemia oncology activation acute ahus atypical chronic cll common cvid differential hemeonc hemolytic hemophagocytic hiv hlh hus
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Leukemia - Summary Cancer ... incompetent • CLL is ... non-Hodgkin lymphoma SLL ... Neutropenia, anemia, thrombocytopenia ... microglobulin Treatment
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
develop leukostasis syndrome ... infiltrates (anemia, thrombocytopenia ... • Tumor lysis syndrome ... lymphoid organs When Cancer ... #Leukemia #Hematology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
• Infectious diarrhea ... Lymphoma or other cancers ... gastric and breast cancer ... Granulomatous lymphocytic ... specifically immune thrombocytopenia
Atypical HUS - Hemolytic Uremic Syndrome Unlike typical HUS, which is shigatoxin mediated, aHUS is not typically
Hemolytic Uremic Syndrome ... autoimmune like SLE ... present with anemia, thrombocytopenia ... Especially if concern ... Hemolytic #Uremic #Syndrome
Acute Retroviral Syndrome Acute Retroviral Syndrome is the symptomatic presentation of acute human immunodeficiency virus infection •
Nausea, vomiting, diarrhea ... • Leukocyte-lymphocyte ... Mild anemia • Thrombocytopenia ... • New onset SLE ... antibody test) Treatment
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Differential Diagnosis Algorithm ... Rebound effect from treatment ... Malignancy: Metastatic cancer ... Vasculitides, IBD ... Kawasaki, Nephrotic syndrome
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
failure • Fever is ... erythematosus [SLE ... leukopenia, anemia, and thrombocytopenia ... Treatment: • Corticosteroids ... Diagnosis #Management #Hematology
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
hyperinflammatory syndrome ... often a cancer. ... Cytopenias (anemia, thrombocytopenia ... Treatment Approach ... Diagnosis #Management #Hematology
Myelodysplastic syndromes current treatment algorithm 2018. From Blood Cancer Journal, Published 24 May 2018 Myelodysplastic syndromes (MDS) are
Myelodysplastic syndromes ... current treatment ... algorithm 2018. ... Myelodysplastic syndromes ... #algorithm #hematology
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